Myxoma T2 protein as a model for poxvirus TNF receptor homologs

G. McFadden*, M. Schreiber, L. Sedger

*Corresponding author for this work

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Many poxviruses encode a plethora of immunomodulatory proteins, including homologs of cellular cytokine receptors. These receptor mimics, also referred to as viroceptors, are believed to function by binding and sequestering host cytokines thus preventing their signaling cascade prior to receptor engagement. The M-T2 protein of myxoma virus is a TNF receptor homolog that has two distinct activities: the secreted dimeric M-T2 protein binds and inhibits TNFα while the intracellular version permits myxoma virus replication in infected T-lymphocytes by blocking the cellular apoptosis response to the virus infection. Studies with M-T2 mutants reveal that distinct protein domains mediate these two anti-immune properties of this protein.

Original languageEnglish
Pages (from-to)119-126
Number of pages8
JournalJournal of Neuroimmunology
Volume72
Issue number2
DOIs
Publication statusPublished - Feb 1997

Keywords

  • apoptosis
  • myxomatosis
  • tumor necrosis factor
  • vaccinia
  • viroceptor
  • virokine

Fingerprint Dive into the research topics of 'Myxoma T2 protein as a model for poxvirus TNF receptor homologs'. Together they form a unique fingerprint.

  • Cite this