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Abstract
Chemical investigation of an undescribed Australian fungus, Aspergillus nanangensis, led to the identification of the nanangenines – a family of seven new and three previously reported drimane sesquiterpenoids. The structures of the nanangenines were elucidated by detailed spectroscopic analysis supported by single crystal X-ray diffraction studies. The compounds were assayed for in vitro activity against bacteria, fungi, mammalian cells and plants. Bioinformatics analysis, including comparative analysis with other acyl drimenol-producing Aspergilli, led to the identification of a putative nanangenine biosynthetic gene cluster that corresponds to the proposed biosynthetic pathway for nanangenines.
Original language | English |
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Pages (from-to) | 2631-2643 |
Number of pages | 13 |
Journal | Beilstein Journal of Organic Chemistry |
Volume | 15 |
DOIs | |
Publication status | Published - 5 Nov 2019 |
Bibliographical note
Copyright the Author(s) 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.Keywords
- Aspergillus
- Biosynthesis
- Drimane
- Secondary metabolites
- Sesquiterpenoid
- Terpenes
Fingerprint
Dive into the research topics of 'Nanangenines: drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, Aspergillus nanangensis'. Together they form a unique fingerprint.Projects
- 1 Finished
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Overcoming antibiotic resistance: rapid discovery of new antibacterial drug targets using chemicalproteomics
Piggott, A., MQRES, M. & MQRES (International), M.
7/04/14 → 6/04/18
Project: Research