@inbook{e72c2b9ff83349b5bb578be6610fc722,
title = "Nanochannel gradient separations",
abstract = "Gradient-based electrophoretic separations enable simultaneous separation and concentration of molecules. Compared with conventional injection-based separations, they enable enrichment of low-concentration analytes from larger sample volumes that are not limited by an injection volume. We have demonstrated that a nanochannel, connecting two chemically different reservoirs, can maintain a stationary chemical gradient while trapping biomolecules and effectively averaging out many of the complex physicochemical hydrodynamics that would broaden the bands in a meso- or microscale capillary. Here we describe chemical and physical methods that enable this work.",
keywords = "Nanofluidic, Fabrication, Conductivity gradient, pH gradient",
author = "Startsev, {Michael A.} and Inglis, {David W.}",
year = "2019",
doi = "10.1007/978-1-4939-8964-5_9",
language = "English",
isbn = "9781493989638",
series = "Methods in Molecular Biology",
publisher = "Humana Press",
pages = "125--132",
editor = "Debashis Dutta",
booktitle = "Microfluidic electrophoresis",
address = "United States",
}