Nanoparticle-mediated singlet oxygen generation from photosensitizers

Sandhya Clement; Mushtaq Sobhan; Wei Deng; Elizabeth Camilleri; Ewa M. Goldys

doi:10.1016/j.jphotochem.2016.08.009

Nanoparticle-mediated singlet oxygen generation from photosensitizers

Sandhya Clement, Mushtaq Sobhan, Wei Deng, Elizabeth Camilleri, Ewa M. Goldys^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

We report on the modification of the efficiency of singlet oxygen generation in photosensitizers conjugated to dielectric (CeF₃) and metal (Au) nanoparticles in water. The conjugates were formed with two photosensitizers, verteporfin and Rose Bengal. Quantitative analysis of the singlet oxygen generation demonstrated that the conjugation of the photosensitizer to a nanoparticle increases the efficiency of the photosensitizers to produce singlet oxygen in water. The singlet oxygen quantum yield of UV-sensitized verteporfin increases by a factor of 1.45 and 1.64 for CeF₃-verteporfin and Au-verteporfin conjugates respectively compared to unconjugated verteporfin. Furthermore, Au-Rose Bengal conjugates also demonstrated enhanced singlet oxygen yield when sensitized at the plasmonic wavelength of 532 nm. We quantitatively explain these findings by the electric field enhancements around the nanoparticles.

Original language	English
Pages (from-to)	66-71
Number of pages	6
Journal	Journal of Photochemistry and Photobiology A: Chemistry
Volume	332
DOIs	https://doi.org/10.1016/j.jphotochem.2016.08.009
Publication status	Published - 1 Jan 2017

Keywords

nanoparticle
photosensitizer
conjugation
singlet oxygen
electric field enhancement
singlet oxygen quantum yiled

Access to Document

10.1016/j.jphotochem.2016.08.009

http://purl.org/au-research/grants/arc/CE140100003

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Cite this

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title = "Nanoparticle-mediated singlet oxygen generation from photosensitizers",

abstract = "We report on the modification of the efficiency of singlet oxygen generation in photosensitizers conjugated to dielectric (CeF3) and metal (Au) nanoparticles in water. The conjugates were formed with two photosensitizers, verteporfin and Rose Bengal. Quantitative analysis of the singlet oxygen generation demonstrated that the conjugation of the photosensitizer to a nanoparticle increases the efficiency of the photosensitizers to produce singlet oxygen in water. The singlet oxygen quantum yield of UV-sensitized verteporfin increases by a factor of 1.45 and 1.64 for CeF3-verteporfin and Au-verteporfin conjugates respectively compared to unconjugated verteporfin. Furthermore, Au-Rose Bengal conjugates also demonstrated enhanced singlet oxygen yield when sensitized at the plasmonic wavelength of 532 nm. We quantitatively explain these findings by the electric field enhancements around the nanoparticles.",

keywords = "nanoparticle, photosensitizer, conjugation, singlet oxygen, electric field enhancement, singlet oxygen quantum yiled",

author = "Sandhya Clement and Mushtaq Sobhan and Wei Deng and Elizabeth Camilleri and Goldys, {Ewa M.}",

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T1 - Nanoparticle-mediated singlet oxygen generation from photosensitizers

AU - Clement, Sandhya

AU - Sobhan, Mushtaq

AU - Deng, Wei

AU - Camilleri, Elizabeth

AU - Goldys, Ewa M.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - We report on the modification of the efficiency of singlet oxygen generation in photosensitizers conjugated to dielectric (CeF3) and metal (Au) nanoparticles in water. The conjugates were formed with two photosensitizers, verteporfin and Rose Bengal. Quantitative analysis of the singlet oxygen generation demonstrated that the conjugation of the photosensitizer to a nanoparticle increases the efficiency of the photosensitizers to produce singlet oxygen in water. The singlet oxygen quantum yield of UV-sensitized verteporfin increases by a factor of 1.45 and 1.64 for CeF3-verteporfin and Au-verteporfin conjugates respectively compared to unconjugated verteporfin. Furthermore, Au-Rose Bengal conjugates also demonstrated enhanced singlet oxygen yield when sensitized at the plasmonic wavelength of 532 nm. We quantitatively explain these findings by the electric field enhancements around the nanoparticles.

AB - We report on the modification of the efficiency of singlet oxygen generation in photosensitizers conjugated to dielectric (CeF3) and metal (Au) nanoparticles in water. The conjugates were formed with two photosensitizers, verteporfin and Rose Bengal. Quantitative analysis of the singlet oxygen generation demonstrated that the conjugation of the photosensitizer to a nanoparticle increases the efficiency of the photosensitizers to produce singlet oxygen in water. The singlet oxygen quantum yield of UV-sensitized verteporfin increases by a factor of 1.45 and 1.64 for CeF3-verteporfin and Au-verteporfin conjugates respectively compared to unconjugated verteporfin. Furthermore, Au-Rose Bengal conjugates also demonstrated enhanced singlet oxygen yield when sensitized at the plasmonic wavelength of 532 nm. We quantitatively explain these findings by the electric field enhancements around the nanoparticles.

KW - nanoparticle

KW - photosensitizer

KW - conjugation

KW - singlet oxygen

KW - electric field enhancement

KW - singlet oxygen quantum yiled

UR - http://purl.org/au-research/grants/arc/CE140100003

U2 - 10.1016/j.jphotochem.2016.08.009

DO - 10.1016/j.jphotochem.2016.08.009

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AN - SCOPUS:84982162700

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SP - 66

EP - 71

JO - Journal of Photochemistry and Photobiology A: Chemistry

JF - Journal of Photochemistry and Photobiology A: Chemistry

SN - 1010-6030

ER -