TY - JOUR
T1 - Nanoparticle-mediated singlet oxygen generation from photosensitizers
AU - Clement, Sandhya
AU - Sobhan, Mushtaq
AU - Deng, Wei
AU - Camilleri, Elizabeth
AU - Goldys, Ewa M.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - We report on the modification of the efficiency of singlet oxygen generation in photosensitizers conjugated to dielectric (CeF3) and metal (Au) nanoparticles in water. The conjugates were formed with two photosensitizers, verteporfin and Rose Bengal. Quantitative analysis of the singlet oxygen generation demonstrated that the conjugation of the photosensitizer to a nanoparticle increases the efficiency of the photosensitizers to produce singlet oxygen in water. The singlet oxygen quantum yield of UV-sensitized verteporfin increases by a factor of 1.45 and 1.64 for CeF3-verteporfin and Au-verteporfin conjugates respectively compared to unconjugated verteporfin. Furthermore, Au-Rose Bengal conjugates also demonstrated enhanced singlet oxygen yield when sensitized at the plasmonic wavelength of 532 nm. We quantitatively explain these findings by the electric field enhancements around the nanoparticles.
AB - We report on the modification of the efficiency of singlet oxygen generation in photosensitizers conjugated to dielectric (CeF3) and metal (Au) nanoparticles in water. The conjugates were formed with two photosensitizers, verteporfin and Rose Bengal. Quantitative analysis of the singlet oxygen generation demonstrated that the conjugation of the photosensitizer to a nanoparticle increases the efficiency of the photosensitizers to produce singlet oxygen in water. The singlet oxygen quantum yield of UV-sensitized verteporfin increases by a factor of 1.45 and 1.64 for CeF3-verteporfin and Au-verteporfin conjugates respectively compared to unconjugated verteporfin. Furthermore, Au-Rose Bengal conjugates also demonstrated enhanced singlet oxygen yield when sensitized at the plasmonic wavelength of 532 nm. We quantitatively explain these findings by the electric field enhancements around the nanoparticles.
KW - nanoparticle
KW - photosensitizer
KW - conjugation
KW - singlet oxygen
KW - electric field enhancement
KW - singlet oxygen quantum yiled
UR - http://purl.org/au-research/grants/arc/CE140100003
U2 - 10.1016/j.jphotochem.2016.08.009
DO - 10.1016/j.jphotochem.2016.08.009
M3 - Article
AN - SCOPUS:84982162700
VL - 332
SP - 66
EP - 71
JO - Journal of Photochemistry and Photobiology A: Chemistry
JF - Journal of Photochemistry and Photobiology A: Chemistry
SN - 1010-6030
ER -