Nanoparticle-mediated singlet oxygen generation from photosensitizers

Sandhya Clement, Mushtaq Sobhan, Wei Deng, Elizabeth Camilleri, Ewa M. Goldys

Research output: Contribution to journalArticleResearchpeer-review

Abstract

We report on the modification of the efficiency of singlet oxygen generation in photosensitizers conjugated to dielectric (CeF3) and metal (Au) nanoparticles in water. The conjugates were formed with two photosensitizers, verteporfin and Rose Bengal. Quantitative analysis of the singlet oxygen generation demonstrated that the conjugation of the photosensitizer to a nanoparticle increases the efficiency of the photosensitizers to produce singlet oxygen in water. The singlet oxygen quantum yield of UV-sensitized verteporfin increases by a factor of 1.45 and 1.64 for CeF3-verteporfin and Au-verteporfin conjugates respectively compared to unconjugated verteporfin. Furthermore, Au-Rose Bengal conjugates also demonstrated enhanced singlet oxygen yield when sensitized at the plasmonic wavelength of 532 nm. We quantitatively explain these findings by the electric field enhancements around the nanoparticles.

LanguageEnglish
Pages66-71
Number of pages6
JournalJournal of Photochemistry and Photobiology A: Chemistry
Volume332
DOIs
Publication statusPublished - 1 Jan 2017

Fingerprint

Singlet Oxygen
Photosensitizing Agents
Photosensitizers
Nanoparticles
nanoparticles
Oxygen
oxygen
Rose Bengal
Water
Metal nanoparticles
Quantum yield
conjugation
water
quantitative analysis
Electric fields
verteporfin
Wavelength
electric fields
augmentation
Chemical analysis

Keywords

  • nanoparticle
  • photosensitizer
  • conjugation
  • singlet oxygen
  • electric field enhancement
  • singlet oxygen quantum yiled

Cite this

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title = "Nanoparticle-mediated singlet oxygen generation from photosensitizers",
abstract = "We report on the modification of the efficiency of singlet oxygen generation in photosensitizers conjugated to dielectric (CeF3) and metal (Au) nanoparticles in water. The conjugates were formed with two photosensitizers, verteporfin and Rose Bengal. Quantitative analysis of the singlet oxygen generation demonstrated that the conjugation of the photosensitizer to a nanoparticle increases the efficiency of the photosensitizers to produce singlet oxygen in water. The singlet oxygen quantum yield of UV-sensitized verteporfin increases by a factor of 1.45 and 1.64 for CeF3-verteporfin and Au-verteporfin conjugates respectively compared to unconjugated verteporfin. Furthermore, Au-Rose Bengal conjugates also demonstrated enhanced singlet oxygen yield when sensitized at the plasmonic wavelength of 532 nm. We quantitatively explain these findings by the electric field enhancements around the nanoparticles.",
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Nanoparticle-mediated singlet oxygen generation from photosensitizers. / Clement, Sandhya; Sobhan, Mushtaq; Deng, Wei; Camilleri, Elizabeth; Goldys, Ewa M.

In: Journal of Photochemistry and Photobiology A: Chemistry, Vol. 332, 01.01.2017, p. 66-71.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Nanoparticle-mediated singlet oxygen generation from photosensitizers

AU - Clement, Sandhya

AU - Sobhan, Mushtaq

AU - Deng, Wei

AU - Camilleri, Elizabeth

AU - Goldys, Ewa M.

PY - 2017/1/1

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N2 - We report on the modification of the efficiency of singlet oxygen generation in photosensitizers conjugated to dielectric (CeF3) and metal (Au) nanoparticles in water. The conjugates were formed with two photosensitizers, verteporfin and Rose Bengal. Quantitative analysis of the singlet oxygen generation demonstrated that the conjugation of the photosensitizer to a nanoparticle increases the efficiency of the photosensitizers to produce singlet oxygen in water. The singlet oxygen quantum yield of UV-sensitized verteporfin increases by a factor of 1.45 and 1.64 for CeF3-verteporfin and Au-verteporfin conjugates respectively compared to unconjugated verteporfin. Furthermore, Au-Rose Bengal conjugates also demonstrated enhanced singlet oxygen yield when sensitized at the plasmonic wavelength of 532 nm. We quantitatively explain these findings by the electric field enhancements around the nanoparticles.

AB - We report on the modification of the efficiency of singlet oxygen generation in photosensitizers conjugated to dielectric (CeF3) and metal (Au) nanoparticles in water. The conjugates were formed with two photosensitizers, verteporfin and Rose Bengal. Quantitative analysis of the singlet oxygen generation demonstrated that the conjugation of the photosensitizer to a nanoparticle increases the efficiency of the photosensitizers to produce singlet oxygen in water. The singlet oxygen quantum yield of UV-sensitized verteporfin increases by a factor of 1.45 and 1.64 for CeF3-verteporfin and Au-verteporfin conjugates respectively compared to unconjugated verteporfin. Furthermore, Au-Rose Bengal conjugates also demonstrated enhanced singlet oxygen yield when sensitized at the plasmonic wavelength of 532 nm. We quantitatively explain these findings by the electric field enhancements around the nanoparticles.

KW - nanoparticle

KW - photosensitizer

KW - conjugation

KW - singlet oxygen

KW - electric field enhancement

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