Nanoplasmonic platforms for bioassays

Zygmunt Gryczynski*, Evgenia Matveeva, Tanya Shtoyko, Ewa Goldys, John Schetz, Julian Borejdo, Nils Calander, Ignacy Gryczynski

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionpeer-review


    Surface-assembled thin molecular layers and nanostructures offer unique opportunities to study processes and mechanisms of macromolecular (protein-protein or/and protein-ligand) interactions. Possibility to capture the conformational information buried in quantum-level interactions offers unique opportunities for the dynamic monitoring of biophysical and biochemical processes at the molecular level. In this report we are presenting novel developments for bioassays with enhanced sensitivity and capabilities due to quantum-photonic interactions of a fluorescent reporter with metallic nanostructures. We discus three cases of plasmons: (1) in nanometer size particles (localized plasmons and metal enhanced fluorescence); (2) in thin metallic film (surface plasmons and directional surface plasmon coupled emeission SPCE); and (3) combination of nanoparticles with continous nanosurfaces (enhanced and directional emission). We will present examples of enhanced immunoassays, background suppression, and applications of this novel technology to the simultaneous measurement of changes in conformation, orientation and mass that occur when biomolecular complexes form.

    Original languageEnglish
    Title of host publication2006 International Symposium on Biophotonics, Nanophotonics and Metamaterials
    Place of PublicationPiscataway, N.J.
    PublisherInstitute of Electrical and Electronics Engineers (IEEE)
    Number of pages1
    ISBN (Electronic)0780397746
    ISBN (Print)0780397738, 9780780397743
    Publication statusPublished - Oct 2006
    EventInternational Symposium on Biophotonics, Nanophotonics and Metamaterials, Metamaterials 2006 - Hangzhou, China
    Duration: 16 Oct 200618 Oct 2006


    OtherInternational Symposium on Biophotonics, Nanophotonics and Metamaterials, Metamaterials 2006


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