TY - JOUR
T1 - Nanosilver-enhanced AIE photosensitizer for simultaneous bioimaging and photodynamic therapy
AU - Tavakkoli Yaraki, Mohammad
AU - Pan, Yutong
AU - Hu, Fang
AU - Liu, Bin
AU - Tan, Yen Nee
N1 - Copyright the Publisher 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.
PY - 2020/10/1
Y1 - 2020/10/1
N2 - Theranostic
photosensitizers which enable both disease diagnosis and effective
treatment have recently received much attention towards personalized
medicine. Herein, we report a multifunctional nanohybrid system using
silver nanoparticles (AgNPs) to enhance the singlet oxygen generation
(SOG) and fluorescence properties of a unique photosensitizer with
aggregation-induced emission (AIE-PS) for simultaneous bioimaging and
photodynamic therapy. To study the metal-enhancement effects,
4-mercaptobenzoic acid-capped AgNPs with well-controlled size (14, 40,
and 80 nm) were synthesized to form nanohybrids with a specially
designed red-emissive AIE-PS via simple electrostatic
interactions. The careful control of the Ag nanoparticle concentration
and the unique design of 80 nm AgNP@red-emissive AIE in this study
resulted in a 10-fold enhancement in SOG, which is higher than other
reported ME-SOG systems using similar plasmonic enhancers. Furthermore,
the as-developed AgNP@AIE-PS nanohybrid exhibited improved
photostability with negligible fluorescence quenching (5%), which is
important for cell tracking. In addition, cytotoxity tests showed that
these nanohybrids are biocompatibile with normal NIH-3T3 cells under
dark conditions. Thus, they were employed for simultaneous imaging and
photodynamic ablation of HeLa cancer cells. The results show that this
brightly fluorescent AgNP@AIE-PS enabled about 4 times higher efficacy
in PDT as compared to the control sample (i.e., 85% vs. 20% cell death) under low intensity white light irradiation (40 mW cm−2) for only 10 minutes, demonstrating its promising potential for advanced theranostic treatment in future nanomedicine.
AB - Theranostic
photosensitizers which enable both disease diagnosis and effective
treatment have recently received much attention towards personalized
medicine. Herein, we report a multifunctional nanohybrid system using
silver nanoparticles (AgNPs) to enhance the singlet oxygen generation
(SOG) and fluorescence properties of a unique photosensitizer with
aggregation-induced emission (AIE-PS) for simultaneous bioimaging and
photodynamic therapy. To study the metal-enhancement effects,
4-mercaptobenzoic acid-capped AgNPs with well-controlled size (14, 40,
and 80 nm) were synthesized to form nanohybrids with a specially
designed red-emissive AIE-PS via simple electrostatic
interactions. The careful control of the Ag nanoparticle concentration
and the unique design of 80 nm AgNP@red-emissive AIE in this study
resulted in a 10-fold enhancement in SOG, which is higher than other
reported ME-SOG systems using similar plasmonic enhancers. Furthermore,
the as-developed AgNP@AIE-PS nanohybrid exhibited improved
photostability with negligible fluorescence quenching (5%), which is
important for cell tracking. In addition, cytotoxity tests showed that
these nanohybrids are biocompatibile with normal NIH-3T3 cells under
dark conditions. Thus, they were employed for simultaneous imaging and
photodynamic ablation of HeLa cancer cells. The results show that this
brightly fluorescent AgNP@AIE-PS enabled about 4 times higher efficacy
in PDT as compared to the control sample (i.e., 85% vs. 20% cell death) under low intensity white light irradiation (40 mW cm−2) for only 10 minutes, demonstrating its promising potential for advanced theranostic treatment in future nanomedicine.
UR - http://www.scopus.com/inward/record.url?scp=85091613063&partnerID=8YFLogxK
U2 - 10.1039/d0qm00469c
DO - 10.1039/d0qm00469c
M3 - Article
SN - 2052-1537
VL - 4
SP - 3074
EP - 3085
JO - Materials Chemistry Frontiers
JF - Materials Chemistry Frontiers
IS - 10
ER -