NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound

Louise E. Wedlock, Matt R. Kilburn, Rong Liu, Jeremy A. Shaw, Susan J. Berners-Price*, Nicholas P. Farrell

*Corresponding author for this work

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Simultaneous multi-element imaging using NanoSIMS (nano-scale secondary ion mass spectrometry), exploiting the novel combination of 195Pt and 15N in platinum-am(m)ine antitumour drugs, provides information on the internalisation and subcellular localisation of both metal and ligands, and allows identification of ligand exchange.

Original languageEnglish
Pages (from-to)6944-6946
Number of pages3
JournalChemical Communications
Volume49
Issue number62
DOIs
Publication statusPublished - 11 Aug 2013
Externally publishedYes

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