NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound

Louise E. Wedlock; Matt R. Kilburn; Rong Liu; Jeremy A. Shaw; Susan J. Berners-Price; Nicholas P. Farrell

doi:10.1039/c3cc42098a

NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound

Louise E. Wedlock, Matt R. Kilburn, Rong Liu, Jeremy A. Shaw, Susan J. Berners-Price^*, Nicholas P. Farrell

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

72 Citations (Scopus)

Abstract

Simultaneous multi-element imaging using NanoSIMS (nano-scale secondary ion mass spectrometry), exploiting the novel combination of ¹⁹⁵Pt and ¹⁵N in platinum-am(m)ine antitumour drugs, provides information on the internalisation and subcellular localisation of both metal and ligands, and allows identification of ligand exchange.

Original language	English
Pages (from-to)	6944-6946
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	62
DOIs	https://doi.org/10.1039/c3cc42098a
Publication status	Published - 11 Aug 2013
Externally published	Yes

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abstract = "Simultaneous multi-element imaging using NanoSIMS (nano-scale secondary ion mass spectrometry), exploiting the novel combination of 195Pt and 15N in platinum-am(m)ine antitumour drugs, provides information on the internalisation and subcellular localisation of both metal and ligands, and allows identification of ligand exchange.",

author = "Wedlock, {Louise E.} and Kilburn, {Matt R.} and Rong Liu and Shaw, {Jeremy A.} and Berners-Price, {Susan J.} and Farrell, {Nicholas P.}",

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AU - Wedlock, Louise E.

AU - Kilburn, Matt R.

AU - Liu, Rong

AU - Shaw, Jeremy A.

AU - Berners-Price, Susan J.

AU - Farrell, Nicholas P.

PY - 2013/8/11

Y1 - 2013/8/11

N2 - Simultaneous multi-element imaging using NanoSIMS (nano-scale secondary ion mass spectrometry), exploiting the novel combination of 195Pt and 15N in platinum-am(m)ine antitumour drugs, provides information on the internalisation and subcellular localisation of both metal and ligands, and allows identification of ligand exchange.

AB - Simultaneous multi-element imaging using NanoSIMS (nano-scale secondary ion mass spectrometry), exploiting the novel combination of 195Pt and 15N in platinum-am(m)ine antitumour drugs, provides information on the internalisation and subcellular localisation of both metal and ligands, and allows identification of ligand exchange.

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M3 - Article

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VL - 49

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EP - 6946

JO - Chemical Communications

JF - Chemical Communications

IS - 62

ER -

NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound

Abstract

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