NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound

Louise E. Wedlock; Matt R. Kilburn; Rong Liu; Jeremy A. Shaw; Susan J. Berners-Price; Nicholas P. Farrell

doi:10.1039/c3cc42098a

NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound

Louise E. Wedlock, Matt R. Kilburn, Rong Liu, Jeremy A. Shaw, Susan J. Berners-Price^*, Nicholas P. Farrell

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

75 Citations (Scopus)

Abstract

Simultaneous multi-element imaging using NanoSIMS (nano-scale secondary ion mass spectrometry), exploiting the novel combination of ¹⁹⁵Pt and ¹⁵N in platinum-am(m)ine antitumour drugs, provides information on the internalisation and subcellular localisation of both metal and ligands, and allows identification of ligand exchange.

Original language	English
Pages (from-to)	6944-6946
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	62
DOIs	https://doi.org/10.1039/c3cc42098a
Publication status	Published - 11 Aug 2013
Externally published	Yes

Access to Document

10.1039/c3cc42098a

Cite this

@article{bbfadac1d3ee423a811908513e79c742,

title = "NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound",

abstract = "Simultaneous multi-element imaging using NanoSIMS (nano-scale secondary ion mass spectrometry), exploiting the novel combination of 195Pt and 15N in platinum-am(m)ine antitumour drugs, provides information on the internalisation and subcellular localisation of both metal and ligands, and allows identification of ligand exchange.",

author = "Wedlock, \{Louise E.\} and Kilburn, \{Matt R.\} and Rong Liu and Shaw, \{Jeremy A.\} and Berners-Price, \{Susan J.\} and Farrell, \{Nicholas P.\}",

year = "2013",

month = aug,

day = "11",

doi = "10.1039/c3cc42098a",

language = "English",

volume = "49",

pages = "6944--6946",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "62",

}

TY - JOUR

T1 - NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound

AU - Wedlock, Louise E.

AU - Kilburn, Matt R.

AU - Liu, Rong

AU - Shaw, Jeremy A.

AU - Berners-Price, Susan J.

AU - Farrell, Nicholas P.

PY - 2013/8/11

Y1 - 2013/8/11

N2 - Simultaneous multi-element imaging using NanoSIMS (nano-scale secondary ion mass spectrometry), exploiting the novel combination of 195Pt and 15N in platinum-am(m)ine antitumour drugs, provides information on the internalisation and subcellular localisation of both metal and ligands, and allows identification of ligand exchange.

AB - Simultaneous multi-element imaging using NanoSIMS (nano-scale secondary ion mass spectrometry), exploiting the novel combination of 195Pt and 15N in platinum-am(m)ine antitumour drugs, provides information on the internalisation and subcellular localisation of both metal and ligands, and allows identification of ligand exchange.

UR - https://www.scopus.com/pages/publications/84882281063

U2 - 10.1039/c3cc42098a

DO - 10.1039/c3cc42098a

M3 - Article

C2 - 23687657

AN - SCOPUS:84882281063

SN - 1359-7345

VL - 49

SP - 6944

EP - 6946

JO - Chemical Communications

JF - Chemical Communications

IS - 62

ER -

NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound

Abstract

Access to Document

Other files and links

Fingerprint

Cite this