Nanovehicles for co-delivery of anticancer agents

Mahdi Zeinali; Soheil Abbaspour-Ravasjani; Marjan Ghorbani; Afshin Babazadeh; Tannaz Soltanfam; Ana  Claudia Santos; Hamed Hamishehkar; Michael  R. Hamblin

doi:10.1016/j.drudis.2020.06.027

Nanovehicles for co-delivery of anticancer agents

Mahdi Zeinali, Soheil Abbaspour-Ravasjani, Marjan Ghorbani, Afshin Babazadeh, Tannaz Soltanfam, Ana Claudia Santos, Hamed Hamishehkar, Michael R. Hamblin^*

^*Corresponding author for this work

Faculty of Medicine, Health and Human Sciences

Research output: Contribution to journal › Review article › peer-review

93 Citations (Scopus)

Abstract

Effective cancer treatment remains a significant challenge in human healthcare. Although many different types of cancer therapy have been tested, scientists have now concluded that combinations of drugs, or drugs plus gene therapy, can target multiple pathways to fight cancer. Nanovehicles can increase drug uptake inside tumor cells, improve biodistribution and accumulation at tumor sites. The ability to deliver two or more anticancer drugs, genes, among others, at the same time and place will increase therapeutic effects while decreasing side effects and reducing the risk of multidrug resistance. This review discusses the advantages of nano-based co-delivery methods in cancer therapy, summarizes the common types of nanovehicles and their preparation methods, and covers some recent co-delivery studies in detail.

Original language	English
Pages (from-to)	1416-1430
Number of pages	15
Journal	Drug Discovery Today
Volume	25
Issue number	8
DOIs	https://doi.org/10.1016/j.drudis.2020.06.027
Publication status	Published - Aug 2020

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10.1016/j.drudis.2020.06.027

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title = "Nanovehicles for co-delivery of anticancer agents",

abstract = "Effective cancer treatment remains a significant challenge in human healthcare. Although many different types of cancer therapy have been tested, scientists have now concluded that combinations of drugs, or drugs plus gene therapy, can target multiple pathways to fight cancer. Nanovehicles can increase drug uptake inside tumor cells, improve biodistribution and accumulation at tumor sites. The ability to deliver two or more anticancer drugs, genes, among others, at the same time and place will increase therapeutic effects while decreasing side effects and reducing the risk of multidrug resistance. This review discusses the advantages of nano-based co-delivery methods in cancer therapy, summarizes the common types of nanovehicles and their preparation methods, and covers some recent co-delivery studies in detail.",

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AU - Zeinali, Mahdi

AU - Abbaspour-Ravasjani, Soheil

AU - Ghorbani, Marjan

AU - Babazadeh, Afshin

AU - Soltanfam, Tannaz

AU - Claudia Santos, Ana

AU - Hamishehkar, Hamed

AU - R. Hamblin, Michael

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N2 - Effective cancer treatment remains a significant challenge in human healthcare. Although many different types of cancer therapy have been tested, scientists have now concluded that combinations of drugs, or drugs plus gene therapy, can target multiple pathways to fight cancer. Nanovehicles can increase drug uptake inside tumor cells, improve biodistribution and accumulation at tumor sites. The ability to deliver two or more anticancer drugs, genes, among others, at the same time and place will increase therapeutic effects while decreasing side effects and reducing the risk of multidrug resistance. This review discusses the advantages of nano-based co-delivery methods in cancer therapy, summarizes the common types of nanovehicles and their preparation methods, and covers some recent co-delivery studies in detail.

AB - Effective cancer treatment remains a significant challenge in human healthcare. Although many different types of cancer therapy have been tested, scientists have now concluded that combinations of drugs, or drugs plus gene therapy, can target multiple pathways to fight cancer. Nanovehicles can increase drug uptake inside tumor cells, improve biodistribution and accumulation at tumor sites. The ability to deliver two or more anticancer drugs, genes, among others, at the same time and place will increase therapeutic effects while decreasing side effects and reducing the risk of multidrug resistance. This review discusses the advantages of nano-based co-delivery methods in cancer therapy, summarizes the common types of nanovehicles and their preparation methods, and covers some recent co-delivery studies in detail.

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DO - 10.1016/j.drudis.2020.06.027

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Nanovehicles for co-delivery of anticancer agents

Abstract

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