Nasal polyps in cystic fibrosis

Patrick O. Sheahan; Richard J. Harvey; Rodney J. Schlosser

doi:10.1007/978-3-642-11412-0_17

Nasal polyps in cystic fibrosis

Patrick O. Sheahan, Richard J. Harvey, Rodney J. Schlosser^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Citation (Scopus)

Abstract

Nasal polyps are common in cystic fibrosis (CF). Nasal polyps in children should prompt appropriate investigations for the potential diagnosis of CF. Possible etiologies for nasal polyp formation in CF include direct consequence of ΔF508 affecting chromosome 7, colonization with microorganisms including Pseudomonas aeroginosa and fungi, and IgE-mediated inflammation. Neutrophils are more common in polyps from CF patients compared with non-CF nasal polyposis. Conservative management with nasal irrigations and nasal steroids constitute first-line treatment. Surgical management of persistent and symptomatic polyps may also improve lung function, and consequently, quality of life. Simple polypectomy has a high rate of early recurrence, and thus, surgery should include at a minimum uncinectomy, middle meatal antrostomy, and anterior ethmoidectomy. Topical delivery of novel medications may reduce the need for surgery.

Original language	English
Title of host publication	Nasal Polyposis: Pathogenesis, Medical and Surgical Treatment
Editors	T. Metin Önerci, Berrylin J. Ferguson
Place of Publication	Berlin Heidelberg
Publisher	Springer, Springer Nature
Pages	145-152
Number of pages	8
ISBN (Print)	9783642114113
DOIs	https://doi.org/10.1007/978-3-642-11412-0_17
Publication status	Published - 2010
Externally published	Yes

Access to Document

10.1007/978-3-642-11412-0_17

Link to publication in Scopus

Fingerprint Dive into the research topics of 'Nasal polyps in cystic fibrosis'. Together they form a unique fingerprint.

Cite this

@inbook{97fb994ce252482d87104a8fad30a7ab,

title = "Nasal polyps in cystic fibrosis",

abstract = "Nasal polyps are common in cystic fibrosis (CF). Nasal polyps in children should prompt appropriate investigations for the potential diagnosis of CF. Possible etiologies for nasal polyp formation in CF include direct consequence of ΔF508 affecting chromosome 7, colonization with microorganisms including Pseudomonas aeroginosa and fungi, and IgE-mediated inflammation. Neutrophils are more common in polyps from CF patients compared with non-CF nasal polyposis. Conservative management with nasal irrigations and nasal steroids constitute first-line treatment. Surgical management of persistent and symptomatic polyps may also improve lung function, and consequently, quality of life. Simple polypectomy has a high rate of early recurrence, and thus, surgery should include at a minimum uncinectomy, middle meatal antrostomy, and anterior ethmoidectomy. Topical delivery of novel medications may reduce the need for surgery.",

author = "Sheahan, {Patrick O.} and Harvey, {Richard J.} and Schlosser, {Rodney J.}",

year = "2010",

doi = "10.1007/978-3-642-11412-0_17",

language = "English",

isbn = "9783642114113",

pages = "145--152",

editor = "{Metin Önerci}, T. and {J. Ferguson}, Berrylin",

booktitle = "Nasal Polyposis: Pathogenesis, Medical and Surgical Treatment",

publisher = "Springer, Springer Nature",

address = "United States",

}

TY - CHAP

T1 - Nasal polyps in cystic fibrosis

AU - Sheahan, Patrick O.

AU - Harvey, Richard J.

AU - Schlosser, Rodney J.

PY - 2010

Y1 - 2010

N2 - Nasal polyps are common in cystic fibrosis (CF). Nasal polyps in children should prompt appropriate investigations for the potential diagnosis of CF. Possible etiologies for nasal polyp formation in CF include direct consequence of ΔF508 affecting chromosome 7, colonization with microorganisms including Pseudomonas aeroginosa and fungi, and IgE-mediated inflammation. Neutrophils are more common in polyps from CF patients compared with non-CF nasal polyposis. Conservative management with nasal irrigations and nasal steroids constitute first-line treatment. Surgical management of persistent and symptomatic polyps may also improve lung function, and consequently, quality of life. Simple polypectomy has a high rate of early recurrence, and thus, surgery should include at a minimum uncinectomy, middle meatal antrostomy, and anterior ethmoidectomy. Topical delivery of novel medications may reduce the need for surgery.

AB - Nasal polyps are common in cystic fibrosis (CF). Nasal polyps in children should prompt appropriate investigations for the potential diagnosis of CF. Possible etiologies for nasal polyp formation in CF include direct consequence of ΔF508 affecting chromosome 7, colonization with microorganisms including Pseudomonas aeroginosa and fungi, and IgE-mediated inflammation. Neutrophils are more common in polyps from CF patients compared with non-CF nasal polyposis. Conservative management with nasal irrigations and nasal steroids constitute first-line treatment. Surgical management of persistent and symptomatic polyps may also improve lung function, and consequently, quality of life. Simple polypectomy has a high rate of early recurrence, and thus, surgery should include at a minimum uncinectomy, middle meatal antrostomy, and anterior ethmoidectomy. Topical delivery of novel medications may reduce the need for surgery.

UR - http://www.scopus.com/inward/record.url?scp=84891447351&partnerID=8YFLogxK

U2 - 10.1007/978-3-642-11412-0_17

DO - 10.1007/978-3-642-11412-0_17

M3 - Chapter

SN - 9783642114113

SP - 145

EP - 152

BT - Nasal Polyposis: Pathogenesis, Medical and Surgical Treatment

A2 - Metin Önerci, T.

A2 - J. Ferguson, Berrylin

PB - Springer, Springer Nature

CY - Berlin Heidelberg

ER -