Nasal polyps in cystic fibrosis

Patrick O. Sheahan, Richard J. Harvey, Rodney J. Schlosser*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Nasal polyps are common in cystic fibrosis (CF). Nasal polyps in children should prompt appropriate investigations for the potential diagnosis of CF. Possible etiologies for nasal polyp formation in CF include direct consequence of ΔF508 affecting chromosome 7, colonization with microorganisms including Pseudomonas aeroginosa and fungi, and IgE-mediated inflammation. Neutrophils are more common in polyps from CF patients compared with non-CF nasal polyposis. Conservative management with nasal irrigations and nasal steroids constitute first-line treatment. Surgical management of persistent and symptomatic polyps may also improve lung function, and consequently, quality of life. Simple polypectomy has a high rate of early recurrence, and thus, surgery should include at a minimum uncinectomy, middle meatal antrostomy, and anterior ethmoidectomy. Topical delivery of novel medications may reduce the need for surgery.

Original languageEnglish
Title of host publicationNasal Polyposis: Pathogenesis, Medical and Surgical Treatment
EditorsT. Metin Önerci, Berrylin J. Ferguson
Place of PublicationBerlin Heidelberg
PublisherSpringer, Springer Nature
Pages145-152
Number of pages8
ISBN (Print)9783642114113
DOIs
Publication statusPublished - 2010
Externally publishedYes

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