Natural products from sponges of the genus Agelas - On the trail of a [2+2]-photoaddition enzyme

Eleanor Hao, Jane Fromont, Daniel Jardine, Peter Karuso

Research output: Contribution to journalArticleResearchpeer-review

Abstract

By specifically targeting sponges likely to contain oroidin derivatives, we have, for the first time, identified Australian sponges that contain sceptrin (2) and related compounds. Using a simple extraction technique and HPLC (with a photodiode array detector) in combination with LC-MS and MS-MS we have been able to quickly identify known compounds and flag the presence of some new compounds in the extracts. Further work will entail isolation and structure elucidation of the new compounds and collection of fresh Agelas sp.1 with the aim of isolating the enzyme that catalyses the [2 + 2] dimerisation or oroidin to sceptrin.

LanguageEnglish
Pages130-141
Number of pages12
JournalMolecules
Volume6
Issue number2
DOIs
Publication statusPublished - Feb 2001

Fingerprint

Agelas
Porifera
Biological Products
enzymes
Dimerization
Enzymes
products
dimerization
Photodiodes
photodiodes
isolation
High Pressure Liquid Chromatography
Derivatives
Detectors
detectors
oroidin
sceptrin

Keywords

  • agelas
  • sceptrin
  • sponge
  • [2+2] photoaddition

Cite this

Hao, Eleanor ; Fromont, Jane ; Jardine, Daniel ; Karuso, Peter. / Natural products from sponges of the genus Agelas - On the trail of a [2+2]-photoaddition enzyme. In: Molecules. 2001 ; Vol. 6, No. 2. pp. 130-141.
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Natural products from sponges of the genus Agelas - On the trail of a [2+2]-photoaddition enzyme. / Hao, Eleanor; Fromont, Jane; Jardine, Daniel; Karuso, Peter.

In: Molecules, Vol. 6, No. 2, 02.2001, p. 130-141.

Research output: Contribution to journalArticleResearchpeer-review

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