Navigating the glycome space and connecting the glycoproteome

Matthew P. Campbell, Robyn A. Peterson, Elisabeth Gasteiger, Julien Mariethoz, Frederique Lisacek, Nicolle H. Packer*

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

    4 Citations (Scopus)

    Abstract

    UniCarbKB (http://unicarbkb.org) is a comprehensive resource for mammalian glycoprotein and annotation data. In particular, the database provides information on the oligosaccharides characterized from a glycoprotein at either the global or site-specific level. This evidence is accumulated from a peer-reviewed and manually curated collection of information on oligosaccharides derived from membrane and secreted glycoproteins purified from biological fluids and/or tissues. This information is further supplemented with experimental method descriptions that summarize important sample preparation and analytical strategies. A new release of UniCarbKB is published every three months, each includes a collection of curated data and improvements to database functionality. In this Chapter, we outline the objectives of UniCarbKB, and describe a selection of step-by-step workflows for navigating the information available. We also provide a short description of web services available and future plans for improving data access. The information presented in this Chapter supplements content available in our knowledgebase including regular updates on interface improvements, new features, and revisions to the database content (http://confluence.unicarbkb.org).

    Original languageEnglish
    Title of host publicationProtein bioinformatics
    Subtitle of host publicationfrom protein modifications and networks to proteomics
    EditorsCathy H. Wu, Cecilia N. Arighi, Karen E. Ross
    Place of PublicationNew York
    PublisherHumana Press
    Chapter7
    Pages139-158
    Number of pages20
    ISBN (Electronic)9781493967834
    ISBN (Print)9781493967810
    DOIs
    Publication statusPublished - 2017

    Publication series

    NameMethods in molecular biology
    PublisherHumana Press
    Volume1558
    ISSN (Print)1064-3745
    ISSN (Electronic)1940-6029

    Keywords

    • Curation
    • Database
    • Glycan
    • Glycobioinformatics
    • Glycomics
    • Glycoproteomics

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