Near infrared light mitigates cerebellar pathology in transgenic mouse models of dementia

Sivaraman Purushothuman, Daniel M. Johnstone*, Charith Nandasena, Janet van Eersel, Lars M. Ittner, John Mitrofanis, Jonathan Stone

*Corresponding author for this work

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

We previously reported that Alzheimer-related pathology in cerebral cortex of APP/PS1 and K3 tau transgenic mouse strains is mitigated by near infrared light (NIr). Here, we extend these observations to the cerebellum. One month of NIr treatment mitigated the deposition of β-amyloid in cerebellar cortex of APP/PS1 mice, and the formation of neurofibrillary tangles, the hyperphosphorylation of tau, the damage caused by oxidative stress and the downregulation of cytochrome oxidase expression by Purkinje cells in the cerebellar cortex of K3 mice. These findings show the ability of NIr to mitigate degeneration in many - probably all - regions of the mouse brain.

Original languageEnglish
Pages (from-to)155-159
Number of pages5
JournalNeuroscience Letters
Volume591
DOIs
Publication statusPublished - 1 Mar 2015
Externally publishedYes

Keywords

  • Dementia
  • Mouse model
  • Near infrared light
  • Neuroprotection

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