TY - JOUR
T1 - Near infrared light mitigates cerebellar pathology in transgenic mouse models of dementia
AU - Purushothuman, Sivaraman
AU - Johnstone, Daniel M.
AU - Nandasena, Charith
AU - van Eersel, Janet
AU - Ittner, Lars M.
AU - Mitrofanis, John
AU - Stone, Jonathan
PY - 2015/3/1
Y1 - 2015/3/1
N2 - We previously reported that Alzheimer-related pathology in cerebral cortex of APP/PS1 and K3 tau transgenic mouse strains is mitigated by near infrared light (NIr). Here, we extend these observations to the cerebellum. One month of NIr treatment mitigated the deposition of β-amyloid in cerebellar cortex of APP/PS1 mice, and the formation of neurofibrillary tangles, the hyperphosphorylation of tau, the damage caused by oxidative stress and the downregulation of cytochrome oxidase expression by Purkinje cells in the cerebellar cortex of K3 mice. These findings show the ability of NIr to mitigate degeneration in many - probably all - regions of the mouse brain.
AB - We previously reported that Alzheimer-related pathology in cerebral cortex of APP/PS1 and K3 tau transgenic mouse strains is mitigated by near infrared light (NIr). Here, we extend these observations to the cerebellum. One month of NIr treatment mitigated the deposition of β-amyloid in cerebellar cortex of APP/PS1 mice, and the formation of neurofibrillary tangles, the hyperphosphorylation of tau, the damage caused by oxidative stress and the downregulation of cytochrome oxidase expression by Purkinje cells in the cerebellar cortex of K3 mice. These findings show the ability of NIr to mitigate degeneration in many - probably all - regions of the mouse brain.
KW - Dementia
KW - Mouse model
KW - Near infrared light
KW - Neuroprotection
UR - http://www.scopus.com/inward/record.url?scp=84923362831&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2015.02.037
DO - 10.1016/j.neulet.2015.02.037
M3 - Article
C2 - 25703226
AN - SCOPUS:84923362831
VL - 591
SP - 155
EP - 159
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
ER -