Network motifs in context: an exploration of the evolution of oscillatory dynamics in transcriptional networks

Jennifer S. Hallinan, Anil Wipat

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionpeer-review

1 Citation (Scopus)

Abstract

The concept of a network motif - a small set of interacting genes which produce a predictable behaviour at the network level - has attracted considerable attention amongst network analysts. It is of particular interest to synthetic biology, a new discipline which aims to apply engineering principles to biological systems. The modular nature of network motifs would make them ideal candidates for the basic components of an engineered organism. In this paper we investigate the relationship between the presence of network motifs and oscillatory dynamics in a yeast transcriptional network and a set of computational networks, evolved to exhibit oscillatory behaviour. Our results do not support the hypothesis that network motifs are critical to network dynamics, possibly because they are tightly connected to many other components of the complex cell-wide transcriptional network.

Original languageEnglish
Title of host publication2008 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology
Place of PublicationPiscataway, NJ
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
Pages83-89
Number of pages7
ISBN (Print)9781424417780
DOIs
Publication statusPublished - 2008
Externally publishedYes
Event2008 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB '08 - Sun Valley, ID, United States
Duration: 15 Sep 200817 Sep 2008

Other

Other2008 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB '08
CountryUnited States
CitySun Valley, ID
Period15/09/0817/09/08

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