Neural changes after phonological treatment for anomia: An fMRI study

Elizabeth Rochon*, Carol Leonard, Hana Burianova, Laura Laird, Peter Soros, Simon Graham, Cheryl Grady

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    37 Citations (Scopus)


    Functional magnetic resonance imaging (fMRI) was used to investigate the neural processing characteristics associated with word retrieval abilities after a phonologically-based treatment for anomia in two stroke patients with aphasia. Neural activity associated with a phonological and a semantic task was compared before and after treatment with fMRI. In addition to the two patients who received treatment, two patients with aphasia who did not receive treatment and 10 healthy controls were also scanned twice. In the two patients who received treatment, both of whose naming improved after treatment, results showed that activation patterns changed after treatment on the semantic task in areas that would have been expected (e.g., left hemisphere frontal and temporal areas). For one control patient, there were no significant changes in brain activation at the second scan; a second control patient showed changes in brain activation at the second scan, on the semantic task, however, these changes were not accompanied with improved performance in naming. In addition, there appeared to be bilateral, or even more right than left hemisphere brain areas activated in this patient than in the treated patients. The healthy control group showed no changes in activation at the second scan. These findings are discussed with reference to the literature on the neural underpinnings of recovery after treatment for anomia in aphasia.

    Original languageEnglish
    Pages (from-to)164-179
    Number of pages16
    JournalBrain and Language
    Issue number3
    Publication statusPublished - Sep 2010


    • Anomia
    • Aphasia
    • FMRI
    • Neuroimaging
    • Treatment


    Dive into the research topics of 'Neural changes after phonological treatment for anomia: An fMRI study'. Together they form a unique fingerprint.

    Cite this