Neural correlates of emotional valence processing in Parkinson’s disease: dysfunction in the subcortex

Peter T. Bell; Moran Gilat; James M. Shine; Katie L. McMahon; Simon J. G. Lewis; David A. Copland

doi:10.1007/s11682-017-9754-3

Neural correlates of emotional valence processing in Parkinson’s disease: dysfunction in the subcortex

Peter T. Bell^*, Moran Gilat, James M. Shine, Katie L. McMahon, Simon J. G. Lewis, David A. Copland

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Parkinson’s disease (PD) is frequently accompanied by cognitive and neuropsychiatric symptoms including impairments in affective processing. Despite this, mechanisms underlying vulnerability to deficits in affective processing remain unclear. In this study, we utilized functional Magnetic Resonance Imaging (fMRI) and an Affective Go-NoGo paradigm, to examine the neural correlates of emotional valence processing in PD. Results suggest that PD is associated with aberrant processing of emotional valence in subcortical limbic structures. Specifically, we found significant group-by-valence interactions in the ventral striatum and amygdala in response to words of differing emotional valence. Our findings contribute to a broader understanding of affective processing in PD and may provide insights into the mechanisms underlying vulnerability to mood disorders in PD.

Original language	English
Pages (from-to)	189-199
Number of pages	11
Journal	Brain Imaging and Behavior
Volume	13
Issue number	1
DOIs	https://doi.org/10.1007/s11682-017-9754-3
Publication status	Published - 15 Feb 2019
Externally published	Yes

Keywords

Amygdala
Dopamine
Emotion
Parkinson’s disease
Ventral striatum

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10.1007/s11682-017-9754-3

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title = "Neural correlates of emotional valence processing in Parkinson{\textquoteright}s disease: dysfunction in the subcortex",

abstract = "Parkinson{\textquoteright}s disease (PD) is frequently accompanied by cognitive and neuropsychiatric symptoms including impairments in affective processing. Despite this, mechanisms underlying vulnerability to deficits in affective processing remain unclear. In this study, we utilized functional Magnetic Resonance Imaging (fMRI) and an Affective Go-NoGo paradigm, to examine the neural correlates of emotional valence processing in PD. Results suggest that PD is associated with aberrant processing of emotional valence in subcortical limbic structures. Specifically, we found significant group-by-valence interactions in the ventral striatum and amygdala in response to words of differing emotional valence. Our findings contribute to a broader understanding of affective processing in PD and may provide insights into the mechanisms underlying vulnerability to mood disorders in PD.",

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author = "Bell, {Peter T.} and Moran Gilat and Shine, {James M.} and McMahon, {Katie L.} and Lewis, {Simon J. G.} and Copland, {David A.}",

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doi = "10.1007/s11682-017-9754-3",

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journal = "Brain Imaging and Behavior",

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T1 - Neural correlates of emotional valence processing in Parkinson’s disease

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AU - Bell, Peter T.

AU - Gilat, Moran

AU - Shine, James M.

AU - McMahon, Katie L.

AU - Lewis, Simon J. G.

AU - Copland, David A.

PY - 2019/2/15

Y1 - 2019/2/15

N2 - Parkinson’s disease (PD) is frequently accompanied by cognitive and neuropsychiatric symptoms including impairments in affective processing. Despite this, mechanisms underlying vulnerability to deficits in affective processing remain unclear. In this study, we utilized functional Magnetic Resonance Imaging (fMRI) and an Affective Go-NoGo paradigm, to examine the neural correlates of emotional valence processing in PD. Results suggest that PD is associated with aberrant processing of emotional valence in subcortical limbic structures. Specifically, we found significant group-by-valence interactions in the ventral striatum and amygdala in response to words of differing emotional valence. Our findings contribute to a broader understanding of affective processing in PD and may provide insights into the mechanisms underlying vulnerability to mood disorders in PD.

AB - Parkinson’s disease (PD) is frequently accompanied by cognitive and neuropsychiatric symptoms including impairments in affective processing. Despite this, mechanisms underlying vulnerability to deficits in affective processing remain unclear. In this study, we utilized functional Magnetic Resonance Imaging (fMRI) and an Affective Go-NoGo paradigm, to examine the neural correlates of emotional valence processing in PD. Results suggest that PD is associated with aberrant processing of emotional valence in subcortical limbic structures. Specifically, we found significant group-by-valence interactions in the ventral striatum and amygdala in response to words of differing emotional valence. Our findings contribute to a broader understanding of affective processing in PD and may provide insights into the mechanisms underlying vulnerability to mood disorders in PD.

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KW - Dopamine

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Neural correlates of emotional valence processing in Parkinson’s disease: dysfunction in the subcortex

Abstract

Keywords

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