Neurofibromatosis 1: Clinical review and exceptions to the rules

Helen Young, Shelley Hyman, Kathryn North*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

47 Citations (Scopus)


Neurofibromatosis 1 is an autosomal dominant, multisystem disorder with myriad clinical manifestations. Between 1991 and 1998, 495 adults and children were diagnosed with neurofibromatosis 1 at a specialized neurogenetics clinic in Sydney, Australia. This review establishes the prevalence of the clinical manifestations of neurofibromatosis 1 in these patients and provides guidelines for assessment and management. In addition, we review in detail patients who had unusual presentations and who represent important "exceptions to the rules" of clinical practice.

Original languageEnglish
Pages (from-to)613-621
Number of pages9
JournalJournal of Child Neurology
Issue number8
Publication statusPublished - 1 Aug 2002
Externally publishedYes

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