Neuronal growth-inhibitory factor (metallothionein-3)

Evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain

Claire Howells, Adrian K. West, Roger S. Chung

Research output: Contribution to journalShort survey

29 Citations (Scopus)

Abstract

Neuronal growth-inhibitory factor, later renamed metallothionein-3, is one of four members of the mammalian metallothionein family. Metallothioneins are a family of ubiquitous, low-molecular-weight, cysteine-rich proteins. Although neuronal growth-inhibitory factor shares metal-binding and reactive oxygen species scavenging properties with the other metallothioneins, it displays several distinct biological properties. In this review, we examine the recent developments regarding the function of neuronal growth-inhibitory factor within the brain, particularly in response to brain injury or during neurodegenerative disease progression.

Original languageEnglish
Pages (from-to)2931-2939
Number of pages9
JournalFEBS Journal
Volume277
Issue number14
DOIs
Publication statusPublished - Jul 2010
Externally publishedYes

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