Neuropeptide Y and peptide YY: important regulators of energy metabolism

Amy D. Nguyen, Herbert Herzog*, Amanda Sainsbury

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

69 Citations (Scopus)

Abstract

Purpose of review

An overview of recent developments documenting the neuropeptide Y (NPY) family's role in energy metabolism. Specifically focusing on site-specific functions of NPY and increasing evidence of peptide YY (PYY) as a weight loss therapeutic.

Recent findings

Studying the NPY family in hypothalamic nuclei, other than the arcuate and paraventricular nuclei, is a recent shift in metabolic research. NPY overexpression in the dorsomedial hypothalamus increases food intake whereas its ablation in this area reduces hyperphagia and obesity. Similarly, NPY exerts orexigenic effects in the ventromedial nucleus. However, specific arcuate Y2 receptor ablation leads to positive energy balance, suggesting the NPY family demonstrates location-specific functions. Peripherally, dual blockade of cannabinoid and NPY pathways has synergistic effects on weight loss, as does combined administration of PYY3-36 and oxyntomodulin in reducing food intake, perhaps due to the recently discovered role of PYY in mediating intestinal Gpr119 activity and controlling glucose tolerance.

Summary

Conditional Y receptor knockout models have provided deeper insights on NPY's functions according to location. Further study of PYY appears vital, due to recent evidence of its role in intestinal motility, with exercise positively influencing PYY levels.

Original languageEnglish
Pages (from-to)56-60
Number of pages5
JournalCurrent Opinion in Endocrinology, Diabetes and Obesity
Volume18
Issue number1
DOIs
Publication statusPublished - Feb 2011
Externally publishedYes

Keywords

  • gut
  • hypothalamus
  • neuropeptide Y
  • obesity
  • peptide YY
  • INHIBITS FOOD-INTAKE
  • RECEPTOR ANTAGONIST RIMONABANT
  • CB1 RECEPTOR
  • BODY-WEIGHT
  • OBESE SUBJECTS
  • BONE-FORMATION
  • KNOCKOUT MICE
  • HOMEOSTASIS
  • RATS
  • OXYNTOMODULIN

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