Neuropharmacological and diuretic activities of Carissa carandas linn. leaf

The crude methanolic extracts of leaves of Carissa carandas Linn. were evaluated for its neuropharmacological and diuretic activities. The extract of Carissa carandas leaves also potentiated the pentobarbital induced sleeping time in mice, and decreased the open field score in open field test, decreased the number of hole crossed from one chamber in the hole cross test and decreased the head dip responses in hole board test. Diuretic activity was proved by the electrolyte loss ratio (Na+/K+ excretion ratio was 1.46 and 1.43 at the doses of 200 and 400 mg/kg respectively) as that of the standard diuretic furosemide (1.48). The obtained results provide a support for the use of this plant in traditional medicine and its further investigation.