Neuropsychiatric effects of insular stroke

F. Manes, S. Paradiso, R. G. Robinson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

69 Citations (Scopus)

Abstract

The neuropsychiatric effects of insular damage in humans have not previously been examined. We therefore examined the neuropsychiatric impairment in seven patients with left insular stroke, six patients with right insular stroke, six patients with left hemisphere noninsular stroke, and six patients with right hemisphere noninsular stroke. Between 4 and 8 weeks after acute stroke, patients were administered a neuropsychiatric battery. Patients with right insular lesions had a greater frequency of subjective anergia and underactivity (Fisher's exact p = .002) as well as tiredness (Fisher's exact p < .002) compared with patients with non-insular lesions or left insular lesions. Subjective feelings of impaired energy or drive after right insular damage may result from disconnection be between the insula and the frontal lobe or the anterior cingulate cortex, structures that have been associated with willed action and motor behavior.

Original languageEnglish
Pages (from-to)707-712
Number of pages6
JournalJournal of Nervous and Mental Disease
Volume187
Issue number12
DOIs
Publication statusPublished - 1999
Externally publishedYes

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