Neurotrophic gene polymorphisms and response to psychological therapy

K. J. Lester*, J. L. Hudson, M. Tropeano, C. Creswell, D. A. Collier, A. Farmer, H. J. Lyneham, R. M. Rapee, T. C. Eley

*Corresponding author for this work

Research output: Contribution to journalReview article

36 Citations (Scopus)
21 Downloads (Pure)

Abstract

Therapygenetics, the study of genetic determinants of response to psychological therapies, is in its infancy. Here, we investigate whether single-nucleotide polymorphisms in nerve growth factor (NGF) (rs6330) and brain-derived neutrotrophic factor (BDNF) (rs6265) genes predict the response to cognitive behaviour therapy (CBT). Neurotrophic genes represent plausible candidate genes: they are implicated in synaptic plasticity, response to stress, and are widely expressed in brain areas involved in mood and cognition. Allelic variation at both loci has shown associations with anxiety-related phenotypes. A sample of 374 anxiety-disordered children with white European ancestry was recruited from clinics in Reading, UK, and in Sydney, Australia. Participants received manualised CBT treatment and DNA was collected from buccal cells using cheek swabs. Treatment response was assessed at post-treatment and follow-up time points. We report first evidence that children with one or more copies of the T allele of NGF rs6330 were significantly more likely to be free of their primary anxiety diagnosis at follow-up (OR0.60 (0.42-0.85), P0.005). These effects remained even when other clinically relevant covariates were accounted for (OR0.62 (0.41-0.92), P0.019). No significant associations were observed between BDNF rs6265 and response to psychological therapy. These findings demonstrate that knowledge of genetic markers has the potential to inform clinical treatment decisions for psychotherapeutic interventions.

Original languageEnglish
Article numbere108
Pages (from-to)1-9
Number of pages9
JournalTranslational Psychiatry
Volume2
DOIs
Publication statusPublished - 2012

Bibliographical note

Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Fingerprint Dive into the research topics of 'Neurotrophic gene polymorphisms and response to psychological therapy'. Together they form a unique fingerprint.

  • Projects

    Cite this

    Lester, K. J., Hudson, J. L., Tropeano, M., Creswell, C., Collier, D. A., Farmer, A., ... Eley, T. C. (2012). Neurotrophic gene polymorphisms and response to psychological therapy. Translational Psychiatry, 2, 1-9. [e108]. https://doi.org/10.1038/tp.2012.33