Neurotrophin-3-like immunoreactivity and Trk C expression in human spinal motoneurones in amyotrophic lateral sclerosis

R. M. Duberley; I. P. Johnson; P. Anand; P. N. Leigh; N. J. Cairns

doi:10.1016/S0022-510X(96)00312-7

Neurotrophin-3-like immunoreactivity and Trk C expression in human spinal motoneurones in amyotrophic lateral sclerosis

R. M. Duberley, I. P. Johnson^*, P. Anand, P. N. Leigh, N. J. Cairns

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

We have demonstrated neurotrophin-3 (NT-3)-like immunoreactivity and tyrosine kinase C (Trk C) receptor expression in motoneurones in postmortem amyotrophic lateral sclerosis (ALS) and control human spinal cord sections. We report that NT-3-like immunoreactivity in motoneurones is decreased in ALS when compared to control tissue. Trk C is expressed in low abundance in both control and ALS motoneurones. These findings are of importance in developing therapeutic strategies for ALS.

Original language	English
Pages (from-to)	33-40
Number of pages	8
Journal	Journal of the Neurological Sciences
Volume	148
Issue number	1
DOIs	https://doi.org/10.1016/S0022-510X(96)00312-7
Publication status	Published - 1 May 1997
Externally published	Yes

Keywords

amyotrophic lateral sclerosis
immunocytochemistry
in situ hybridisation
motoneurones
neurotrophin-3
Trk C

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10.1016/S0022-510X(96)00312-7

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title = "Neurotrophin-3-like immunoreactivity and Trk C expression in human spinal motoneurones in amyotrophic lateral sclerosis",

abstract = "We have demonstrated neurotrophin-3 (NT-3)-like immunoreactivity and tyrosine kinase C (Trk C) receptor expression in motoneurones in postmortem amyotrophic lateral sclerosis (ALS) and control human spinal cord sections. We report that NT-3-like immunoreactivity in motoneurones is decreased in ALS when compared to control tissue. Trk C is expressed in low abundance in both control and ALS motoneurones. These findings are of importance in developing therapeutic strategies for ALS.",

keywords = "amyotrophic lateral sclerosis, immunocytochemistry, in situ hybridisation, motoneurones, neurotrophin-3, Trk C",

author = "Duberley, {R. M.} and Johnson, {I. P.} and P. Anand and Leigh, {P. N.} and Cairns, {N. J.}",

year = "1997",

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doi = "10.1016/S0022-510X(96)00312-7",

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T1 - Neurotrophin-3-like immunoreactivity and Trk C expression in human spinal motoneurones in amyotrophic lateral sclerosis

AU - Duberley, R. M.

AU - Johnson, I. P.

AU - Anand, P.

AU - Leigh, P. N.

AU - Cairns, N. J.

PY - 1997/5/1

Y1 - 1997/5/1

N2 - We have demonstrated neurotrophin-3 (NT-3)-like immunoreactivity and tyrosine kinase C (Trk C) receptor expression in motoneurones in postmortem amyotrophic lateral sclerosis (ALS) and control human spinal cord sections. We report that NT-3-like immunoreactivity in motoneurones is decreased in ALS when compared to control tissue. Trk C is expressed in low abundance in both control and ALS motoneurones. These findings are of importance in developing therapeutic strategies for ALS.

AB - We have demonstrated neurotrophin-3 (NT-3)-like immunoreactivity and tyrosine kinase C (Trk C) receptor expression in motoneurones in postmortem amyotrophic lateral sclerosis (ALS) and control human spinal cord sections. We report that NT-3-like immunoreactivity in motoneurones is decreased in ALS when compared to control tissue. Trk C is expressed in low abundance in both control and ALS motoneurones. These findings are of importance in developing therapeutic strategies for ALS.

KW - amyotrophic lateral sclerosis

KW - immunocytochemistry

KW - in situ hybridisation

KW - motoneurones

KW - neurotrophin-3

KW - Trk C

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DO - 10.1016/S0022-510X(96)00312-7

M3 - Article

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AN - SCOPUS:0031148557

SN - 0022-510X

VL - 148

SP - 33

EP - 40

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

IS - 1

ER -

Neurotrophin-3-like immunoreactivity and Trk C expression in human spinal motoneurones in amyotrophic lateral sclerosis

Abstract

Keywords

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