Neurotrophin-3-like immunoreactivity and Trk C expression in human spinal motoneurones in amyotrophic lateral sclerosis

R. M. Duberley, I. P. Johnson*, P. Anand, P. N. Leigh, N. J. Cairns

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

We have demonstrated neurotrophin-3 (NT-3)-like immunoreactivity and tyrosine kinase C (Trk C) receptor expression in motoneurones in postmortem amyotrophic lateral sclerosis (ALS) and control human spinal cord sections. We report that NT-3-like immunoreactivity in motoneurones is decreased in ALS when compared to control tissue. Trk C is expressed in low abundance in both control and ALS motoneurones. These findings are of importance in developing therapeutic strategies for ALS.

Original languageEnglish
Pages (from-to)33-40
Number of pages8
JournalJournal of the Neurological Sciences
Volume148
Issue number1
DOIs
Publication statusPublished - 1 May 1997
Externally publishedYes

Keywords

  • amyotrophic lateral sclerosis
  • immunocytochemistry
  • in situ hybridisation
  • motoneurones
  • neurotrophin-3
  • Trk C

Fingerprint

Dive into the research topics of 'Neurotrophin-3-like immunoreactivity and Trk C expression in human spinal motoneurones in amyotrophic lateral sclerosis'. Together they form a unique fingerprint.

Cite this