New antimicrobial bromotyrosine analogues from the sponge Pseudoceratina purpurea and its predator Tylodina corticalis

Michael P. Gotsbacher, Peter Karuso

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Bioassay-guided fractionation of extracts from temperate Australian collections of the marine sponge Pseudoceratina purpurea resulted in the isolation and characterisation of two new and six known bromotyrosine-derived alkaloids with antibiotic activity. Surprisingly, a single specimen of the mollusc Tylodina corticalis, which was collected while feeding on P. purpurea, contained only a few of the compounds found in the sponge suggesting selective accumulation and chemical modification of sponge metabolites.

LanguageEnglish
Pages1389-1409
Number of pages21
JournalMarine Drugs
Volume13
Issue number3
DOIs
Publication statusPublished - 1 Mar 2015

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Porifera
Mollusca
Alkaloids
Biological Assay
Anti-Bacterial Agents
bromotyrosine

Bibliographical note

Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Cite this

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New antimicrobial bromotyrosine analogues from the sponge Pseudoceratina purpurea and its predator Tylodina corticalis. / Gotsbacher, Michael P.; Karuso, Peter.

In: Marine Drugs, Vol. 13, No. 3, 01.03.2015, p. 1389-1409.

Research output: Contribution to journalArticleResearchpeer-review

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