New insights into the breathing physiology from transient respiratory nasal simulation

Kimberley Bradshaw, Patrick Warfield-Mcalpine, Sara Vahaji, Jake Emmerling, Hana Salati, Ray Sacks, David F. Fletcher, Narinder Singh, Kiao Inthavong*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

The flow characteristics and heat transfer during nasal breathing in the complete human upper airway were investigated through the respiratory cycle using transient numerical simulations. We postulate that the complete airway from the nasal cavity to the trachea most accurately represents dynamic airflow patterns during inhalation and exhalation as they are likely to be affected by downstream anatomical structures. A 3D model was constructed from a healthy adult computed tomography scan. Computational fluid dynamics simulations were performed with Ansys Fluent software [ANSYS Fluent, R1 User's Guide (ANSYS, Inc., 2020)] using the stress-blended eddy simulation turbulence model looking at airflow patterns, velocity, mucosal temperature, and humidity (H2O fraction). One and a half breathing cycles were simulated for a total of 5.65 s, where the first inhalation cycle was discarded to avoid start-up effects. The results demonstrated that airway geometry structures, including the turbinates, the soft palate, and the glottic region, affect the flow patterns differently during inspiration and expiration. It also demonstrated phenomena not seen in steady flow simulations or in those without the lower respiratory tract geometry, including the nasopharyngeal temperature imprint during inhalation, the nasopharyngeal jet during exhalation, and the flow structures of the larynx and laryngeal jet. The inclusion of the exhalation phase demonstrates airflow preconditioning before inhalation, which we postulate contributes to achieving alveolar conditions. Alveolar temperature and humidity conditions are not achieved by the nasal cavity alone, and we demonstrate the contribution of the nasopharynx and larynx to air conditioning. Including the complete airway with realistic anatomy and using transient airflow modeling provided new insights into the physiology of the respiratory cycle.

Original languageEnglish
Article number115103
Pages (from-to)1-14
Number of pages14
JournalPhysics of Fluids
Volume34
Issue number11
DOIs
Publication statusPublished - 1 Nov 2022
Externally publishedYes

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