New insights into the protective power of platelets in malaria infection

Brendan J. McMorran; Gaetan Burgio; Simon J. Foote

doi:10.4161/cib.23653

New insights into the protective power of platelets in malaria infection

Brendan J. McMorran^*, Gaetan Burgio, Simon J. Foote

^*Corresponding author for this work

Macquarie University BioFocus Research Centre

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

20 Downloads (Pure)

Abstract

Platelets, as well as regulating blood hemostasis, are an important component of thebody's defense against invading microbial pathogens. We previously reported that platelets protect during malaria infection by binding Plasmodiuminfected erythrocytes (IE) and killing the parasite within. More recent studies have now revealed the platelet plasmocidalfactor, platelet factor 4 (PF4) and the red cell-expressed Duffyantigen molecule as the central players in the parasite killing activity of platelets.

Original language	English
Article number	e23653
Pages (from-to)	e23653-1-e23653-4
Number of pages	4
Journal	Communicative and Integrative Biology
Volume	6
Issue number	3
DOIs	https://doi.org/10.4161/cib.23653
Publication status	Published - May 2013

Bibliographical note

Copyright the Author(s) 2013. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

Duffy-antigen
Innate immunity
Malaria
Plasmodium falciparum
Platelet
Platelet factor 4

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10.4161/cib.23653

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New insights into the protective power of platelets in malaria infection

Abstract

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Keywords

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