New insights into the protective power of platelets in malaria infection

Brendan J. McMorran*, Gaetan Burgio, Simon J. Foote

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)
15 Downloads (Pure)

Abstract

Platelets, as well as regulating blood hemostasis, are an important component of thebody's defense against invading microbial pathogens. We previously reported that platelets protect during malaria infection by binding Plasmodiuminfected erythrocytes (IE) and killing the parasite within. More recent studies have now revealed the platelet plasmocidalfactor, platelet factor 4 (PF4) and the red cell-expressed Duffyantigen molecule as the central players in the parasite killing activity of platelets.

Original languageEnglish
Article numbere23653
Pages (from-to)e23653-1-e23653-4
Number of pages4
JournalCommunicative and Integrative Biology
Volume6
Issue number3
DOIs
Publication statusPublished - May 2013

Bibliographical note

Copyright the Author(s) 2013. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • Duffy-antigen
  • Innate immunity
  • Malaria
  • Plasmodium falciparum
  • Platelet
  • Platelet factor 4

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