Night-time brain inter-hemispheric asynchrony in sleep apnea patients carry information on neuropsychological impairment

Vinayak R. Swarnkar, Udantha R. Abeyratne, Brett Duce, Roneel V. Sharan, Craig Hukins, Karen McCloy

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contribution

Abstract

Obstructive sleep apnea (OSA) is a serious sleep disorder with diurnal symptoms including neuropsychological impairments such as excessive daytime sleepiness and loss of attention. There are no efficient tools to measure these impairments in current clinical practice. In this paper, we explore the feasibility of measuring neuropsychological impairments using electroencephalography (EEG) data acquired during the standard clinical sleep diagnostic test known as polysomnography (PSG). We hypothesized that left-right hemispheric EEG asynchrony could quantitatively characterize neuropsychological impairment in OSA in a population of sleep laboratory patients. We acquired EEG data from 50 subjects undergoing routine PSG, using symmetric electrode derivations of C4-A2 and C3-A1. Their neuropsychological performance was assessed via a psychomotor vigilance task (PVT). We computed the left-right EEG asynchrony and developed a logistic regression model (LRM) to classify patients according to their PVT performance. Leave-one-out cross-validation studies on a LRM model with two-class PVT performance achieved a sensitivity of 83% (95% CI: 66-100%) and a specificity of 78% (95% CI: 64-92%). These results indicate that EEG asynchrony during sleep carries information on daytime neuropsychological impairments in OSA subjects.

Original languageEnglish
Title of host publication2019 IEEE Biomedical Circuits and Systems Conference
Place of PublicationPiscataway, NJ
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
Pages1-4
Number of pages4
ISBN (Electronic)9781509006175
ISBN (Print)9781509006182
DOIs
Publication statusPublished - 1 Oct 2019
Event2019 IEEE Biomedical Circuits and Systems Conference, BioCAS 2019 - Nara, Japan
Duration: 17 Oct 201919 Oct 2019

Conference

Conference2019 IEEE Biomedical Circuits and Systems Conference, BioCAS 2019
CountryJapan
CityNara
Period17/10/1919/10/19

Keywords

  • asynchrony
  • electroencephalography
  • neuropsychological
  • obstructive sleep apnea
  • psychomotor vigilance task

Fingerprint Dive into the research topics of 'Night-time brain inter-hemispheric asynchrony in sleep apnea patients carry information on neuropsychological impairment'. Together they form a unique fingerprint.

  • Cite this

    Swarnkar, V. R., Abeyratne, U. R., Duce, B., Sharan, R. V., Hukins, C., & McCloy, K. (2019). Night-time brain inter-hemispheric asynchrony in sleep apnea patients carry information on neuropsychological impairment. In 2019 IEEE Biomedical Circuits and Systems Conference (pp. 1-4). [8919147] Piscataway, NJ: Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/BIOCAS.2019.8919147