Nitroglycerin has more favourable effects on left ventricular afterload than apparent from measurement of pressure in a peripheral artery

R. P. Kelly, H. H. Gibbs, M. F. O'Rourke*, J. E. Daley, K. Mang, J. J. Morgan, A. P. Avolio

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

263 Citations (Scopus)

Abstract

Nitroglycerin (0.3 mg) was administered sublingually to 14 patients undergoing cardiac catheterization, and pressure waves compared in the ascending aorta and brachial artery. After nitroglycerin, ascending aortic systolic pressure fell in all cases (by 6-44, average 22 mmHg) whereas brachial systolic pressure remained unchanged (in three) or fell to a lesser degree (4-33, average 12 mmHg). Diastolic pressure did not change significantly. Alterations in pressure and in wave contour were explained on the basis of arterial dilation, with reduction in wave reflection. Nitroglycerin reduces left ventricular afterload through arterial dilation as well as preload through venous dilation. This effect on afterload is not apparent from measurement of pressure in the brachial artery.

Original languageEnglish
Pages (from-to)138-144
Number of pages7
JournalEuropean Heart Journal
Volume11
Issue number2
Publication statusPublished - 1990
Externally publishedYes

Keywords

  • Afterload
  • Nitroglycerin
  • Wave reflection

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