No association of presenilin-1 intronic polymorphism and Alzheimer's disease in Australia

K. Taddei, D. Yang, C. Fisher, R. Clarnette, J. Hallmayer, R. Barnetson, R. Maller, W. S. Brooks, S. Whyte, G. A. Nicholson, C. L. Masters, G. A. Broe, S. E. Gandy, R. N. Martins*

*Corresponding author for this work

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We screened 703 Australian subjects for an intronic polymorphism in the presenilin-1 (PS-1) gene. PS-1 intronic allele 1 homozygosity was not associated with individuals with early- or late-onset sporadic Alzheimer's disease (EOAD or LOAD). Carriers for the PS-1 intronic allele 1 were also not associated with significantly increased risk for AD regardless of gender. Our results for the Australian population are consistent with those of recent reports for other populations and do no support the conclusion that the PS-1 intronic polymorphism is associated with AD.

Original languageEnglish
Pages (from-to)178-180
Number of pages3
JournalNeuroscience Letters
Volume246
Issue number3
DOIs
Publication statusPublished - 10 Apr 1998
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Chromosome
  • Genetics
  • Intronic polymorphism
  • Presenilin-1

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