No association of presenilin-1 intronic polymorphism and Alzheimer's disease in Australia

K. Taddei; D. Yang; C. Fisher; R. Clarnette; J. Hallmayer; R. Barnetson; R. Maller; W. S. Brooks; S. Whyte; G. A. Nicholson; C. L. Masters; G. A. Broe; S. E. Gandy; R. N. Martins

doi:10.1016/S0304-3940(98)00248-1

No association of presenilin-1 intronic polymorphism and Alzheimer's disease in Australia

K. Taddei, D. Yang, C. Fisher, R. Clarnette, J. Hallmayer, R. Barnetson, R. Maller, W. S. Brooks, S. Whyte, G. A. Nicholson, C. L. Masters, G. A. Broe, S. E. Gandy, R. N. Martins^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

We screened 703 Australian subjects for an intronic polymorphism in the presenilin-1 (PS-1) gene. PS-1 intronic allele 1 homozygosity was not associated with individuals with early- or late-onset sporadic Alzheimer's disease (EOAD or LOAD). Carriers for the PS-1 intronic allele 1 were also not associated with significantly increased risk for AD regardless of gender. Our results for the Australian population are consistent with those of recent reports for other populations and do no support the conclusion that the PS-1 intronic polymorphism is associated with AD.

Original language	English
Pages (from-to)	178-180
Number of pages	3
Journal	Neuroscience Letters
Volume	246
Issue number	3
DOIs	https://doi.org/10.1016/S0304-3940(98)00248-1
Publication status	Published - 10 Apr 1998
Externally published	Yes

Keywords

Alzheimer's disease
Chromosome
Genetics
Intronic polymorphism
Presenilin-1

Access to Document

10.1016/S0304-3940(98)00248-1

Cite this

Taddei, K., Yang, D., Fisher, C., Clarnette, R., Hallmayer, J., Barnetson, R., Maller, R., Brooks, W. S., Whyte, S., Nicholson, G. A., Masters, C. L., Broe, G. A., Gandy, S. E., & Martins, R. N. (1998). No association of presenilin-1 intronic polymorphism and Alzheimer's disease in Australia. Neuroscience Letters, 246(3), 178-180. https://doi.org/10.1016/S0304-3940(98)00248-1

@article{1a010434bc93438f922035ffe8c99c6d,

title = "No association of presenilin-1 intronic polymorphism and Alzheimer's disease in Australia",

abstract = "We screened 703 Australian subjects for an intronic polymorphism in the presenilin-1 (PS-1) gene. PS-1 intronic allele 1 homozygosity was not associated with individuals with early- or late-onset sporadic Alzheimer's disease (EOAD or LOAD). Carriers for the PS-1 intronic allele 1 were also not associated with significantly increased risk for AD regardless of gender. Our results for the Australian population are consistent with those of recent reports for other populations and do no support the conclusion that the PS-1 intronic polymorphism is associated with AD.",

keywords = "Alzheimer's disease, Chromosome, Genetics, Intronic polymorphism, Presenilin-1",

author = "K. Taddei and D. Yang and C. Fisher and R. Clarnette and J. Hallmayer and R. Barnetson and R. Maller and Brooks, \{W. S.\} and S. Whyte and Nicholson, \{G. A.\} and Masters, \{C. L.\} and Broe, \{G. A.\} and Gandy, \{S. E.\} and Martins, \{R. N.\}",

year = "1998",

month = apr,

day = "10",

doi = "10.1016/S0304-3940(98)00248-1",

language = "English",

volume = "246",

pages = "178--180",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - No association of presenilin-1 intronic polymorphism and Alzheimer's disease in Australia

AU - Taddei, K.

AU - Yang, D.

AU - Fisher, C.

AU - Clarnette, R.

AU - Hallmayer, J.

AU - Barnetson, R.

AU - Maller, R.

AU - Brooks, W. S.

AU - Whyte, S.

AU - Nicholson, G. A.

AU - Masters, C. L.

AU - Broe, G. A.

AU - Gandy, S. E.

AU - Martins, R. N.

PY - 1998/4/10

Y1 - 1998/4/10

N2 - We screened 703 Australian subjects for an intronic polymorphism in the presenilin-1 (PS-1) gene. PS-1 intronic allele 1 homozygosity was not associated with individuals with early- or late-onset sporadic Alzheimer's disease (EOAD or LOAD). Carriers for the PS-1 intronic allele 1 were also not associated with significantly increased risk for AD regardless of gender. Our results for the Australian population are consistent with those of recent reports for other populations and do no support the conclusion that the PS-1 intronic polymorphism is associated with AD.

AB - We screened 703 Australian subjects for an intronic polymorphism in the presenilin-1 (PS-1) gene. PS-1 intronic allele 1 homozygosity was not associated with individuals with early- or late-onset sporadic Alzheimer's disease (EOAD or LOAD). Carriers for the PS-1 intronic allele 1 were also not associated with significantly increased risk for AD regardless of gender. Our results for the Australian population are consistent with those of recent reports for other populations and do no support the conclusion that the PS-1 intronic polymorphism is associated with AD.

KW - Alzheimer's disease

KW - Chromosome

KW - Genetics

KW - Intronic polymorphism

KW - Presenilin-1

UR - https://www.scopus.com/pages/publications/0032502591

U2 - 10.1016/S0304-3940(98)00248-1

DO - 10.1016/S0304-3940(98)00248-1

M3 - Article

C2 - 9792621

AN - SCOPUS:0032502591

SN - 0304-3940

VL - 246

SP - 178

EP - 180

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 3

ER -

No association of presenilin-1 intronic polymorphism and Alzheimer's disease in Australia

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this