No overt deficits in aged tau-deficient C57Bl/6.Mapttm1(EGFP)kit GFP knockin mice

Annika Van Hummel, Mian Bi, Stefania Ippati, Julia van der Hoven, Alexander Volkerling, Wei S. Lee, Daniel C. S. Tan, Andre Bongers, Arne Ittner, Yazi D. Ke, Lars M. Ittner*

*Corresponding author for this work

Research output: Contribution to journalArticle

18 Citations (Scopus)
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Abstract

Several mouse lines with knockout of the tau-encoding MAPT gene have been reported in the past; they received recent attention due to reports that tau reduction prevented Aβ-induced deficits in mouse models of Alzheimer's disease. However, the effects of long-term depletion of tau in vivo remained controversial. Here, we used the tau-deficient GFP knockin line Mapttm1(EGFP)kit on a pure C57Bl/6 background and subjected a large cohort of males and females to a range of motor, memory and behavior tests and imaging analysis, at the advanced age of over 16 months. Neither heterozygous nor homozygous Mapttm1(EGFP)kit mice presented with deficits or abnormalities compared to wild-type littermates. Differences to reports using other tau knockout models may be due to different genetic backgrounds, respective gene targeting strategies or other confounding factors, such as nutrition. To this end, we report no functional or morphological deficits upon tau reduction or depletion in aged mice.

Original languageEnglish
Article numbere0163236
Pages (from-to)1-14
Number of pages14
JournalPLoS ONE
Volume11
Issue number10
DOIs
Publication statusPublished - 13 Oct 2016
Externally publishedYes

Bibliographical note

Copyright the Author(s) 2016. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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