TY - JOUR
T1 - No overt deficits in aged tau-deficient C57Bl/6.Mapttm1(EGFP)kit GFP knockin mice
AU - Van Hummel, Annika
AU - Bi, Mian
AU - Ippati, Stefania
AU - van der Hoven, Julia
AU - Volkerling, Alexander
AU - Lee, Wei S.
AU - Tan, Daniel C. S.
AU - Bongers, Andre
AU - Ittner, Arne
AU - Ke, Yazi D.
AU - Ittner, Lars M.
N1 - Copyright the Author(s) 2016. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.
PY - 2016/10/13
Y1 - 2016/10/13
N2 - Several mouse lines with knockout of the tau-encoding MAPT gene have been reported in the past; they received recent attention due to reports that tau reduction prevented Aβ-induced deficits in mouse models of Alzheimer's disease. However, the effects of long-term depletion of tau in vivo remained controversial. Here, we used the tau-deficient GFP knockin line Mapttm1(EGFP)kit on a pure C57Bl/6 background and subjected a large cohort of males and females to a range of motor, memory and behavior tests and imaging analysis, at the advanced age of over 16 months. Neither heterozygous nor homozygous Mapttm1(EGFP)kit mice presented with deficits or abnormalities compared to wild-type littermates. Differences to reports using other tau knockout models may be due to different genetic backgrounds, respective gene targeting strategies or other confounding factors, such as nutrition. To this end, we report no functional or morphological deficits upon tau reduction or depletion in aged mice.
AB - Several mouse lines with knockout of the tau-encoding MAPT gene have been reported in the past; they received recent attention due to reports that tau reduction prevented Aβ-induced deficits in mouse models of Alzheimer's disease. However, the effects of long-term depletion of tau in vivo remained controversial. Here, we used the tau-deficient GFP knockin line Mapttm1(EGFP)kit on a pure C57Bl/6 background and subjected a large cohort of males and females to a range of motor, memory and behavior tests and imaging analysis, at the advanced age of over 16 months. Neither heterozygous nor homozygous Mapttm1(EGFP)kit mice presented with deficits or abnormalities compared to wild-type littermates. Differences to reports using other tau knockout models may be due to different genetic backgrounds, respective gene targeting strategies or other confounding factors, such as nutrition. To this end, we report no functional or morphological deficits upon tau reduction or depletion in aged mice.
UR - http://www.scopus.com/inward/record.url?scp=84991461460&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0163236
DO - 10.1371/journal.pone.0163236
M3 - Article
C2 - 27736877
AN - SCOPUS:84991461460
SN - 1932-6203
VL - 11
SP - 1
EP - 14
JO - PLoS ONE
JF - PLoS ONE
IS - 10
M1 - e0163236
ER -