Nocardioazines: A novel bridged diketopiperazine scaffold from a marine-derived bacterium inhibits p-glycoprotein

Ritesh Raju*, Andrew M. Piggott, Xiao Cong Huang, Robert J. Capon

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

82 Citations (Scopus)

Abstract

An Australian marine sediment-derived isolate, Nocardiopsis sp. (CMB-M0232), yielded a new class of prenylated diketopiperazine, indicative of the action of a uniquely regioselective diketopiperazine indole prenyltransferase. The bridged scaffold of nocardioazine A proved to be a noncytotoxic inhibitor of the membrane protein efflux pump P-glycoprotein, reversing doxorubicin resistance in a multidrug resistant colon cancer cell.

Original languageEnglish
Pages (from-to)2770-2773
Number of pages4
JournalOrganic Letters
Volume13
Issue number10
DOIs
Publication statusPublished - 20 May 2011
Externally publishedYes

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