Nocardiopsins C and D and nocardiopyrone A

New polyketides from an Australian marine-derived Nocardiopsis sp.

Ritesh Raju, Andrew M. Piggott, Michelle Quezada, Robert J. Capon*

*Corresponding author for this work

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A Nocardiopsis sp. (CMB-M0232) recovered from marine sediment collected off the coast of South Molle Island, Queensland, Australia, yielded two new examples of rare prolinyl-macrolactam polyketides, nocardiopsins C (1) and D (2), a new highly substituted α-pyrone polyketide, nocardiopyrone A (3), and the previously reported macrolide polyketides nocardiopsins A (4) and B (5). Structures were assigned on the basis of detailed spectroscopic analysis, degradation, and chemical derivatization. PCR amplification of CMB-M0232 genomic DNA revealed the presence of type I and type II polyketide synthase and nonribosomal peptide synthase domains.

Original languageEnglish
Pages (from-to)692-698
Number of pages7
JournalTetrahedron
Volume69
Issue number2
DOIs
Publication statusPublished - 14 Jan 2013
Externally publishedYes

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Keywords

  • α-pyrone polyketides
  • Marine-derived actinomycetes
  • Microbial natural products chemistry
  • Nocardiopsis
  • Prolinyl-macrolactam polyketides

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