Non-invasive assessment of exhaled biomarkers in lung transplantation

Deborah H. Yates*, Anu Krishnan, Sharron Chow, Paul S. Thomas

*Corresponding author for this work

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

Biomarkers in exhaled breath condensate (EBC) and fractional exhaled nitric oxide (FeNO) have been widely evaluated in respiratory research as non-invasive methods of sampling the lungs. These methods are particularly attractive in lung transplantation (LTx) as they are simple, repeatable and sensitive. Chronic rejection, manifest by progressive airflow limitation and bronchiolitis obliterans syndrome (BOS), is currently the major limiting factor to long-term survival in LTx. Early detection of BOS and initiation of appropriate treatment could significantly improve survival. Exhaled breath biomarkers could allow early diagnosis of factors associated with chronic rejection. FeNO is elevated in LTx patients with infections and chronic rejection prior to clinical presentation, and several EBC biomarkers and volatile organic compound patterns also show promise in these areas. This review summarizes information on exhaled breath biomarkers in LTx and discusses their potential role in the management of LTx patients.

Original languageEnglish
Article number024001
Pages (from-to)1-11
Number of pages11
JournalJournal of Breath Research
Volume5
Issue number2
DOIs
Publication statusPublished - Jun 2011
Externally publishedYes

Keywords

  • BRONCHIOLITIS OBLITERANS SYNDROME
  • OBSTRUCTIVE PULMONARY-DISEASE
  • BREATH CONDENSATE PH
  • NITRIC-OXIDE LEVELS
  • ALLOGRAFT-REJECTION
  • OXIDATIVE STRESS
  • EXPIRED BREATH
  • BRONCHOALVEOLAR LAVAGE
  • AIRWAY OBLITERATION
  • HYDROGEN-PEROXIDE

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