Non-invasive estimation of intracranial pressure by means of retinal venous pulsatility

S. Mojtaba Golzan; Stuart L. Graham; Alberto Avolio

doi:10.1007/978-3-642-14998-6_22

Non-invasive estimation of intracranial pressure by means of retinal venous pulsatility

S. Mojtaba Golzan, Stuart L. Graham, Alberto Avolio

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review

2 Citations (Scopus)

Abstract

Current techniques used to measure intracranial pressure (ICP) are invasive and require surgical procedures in order to implant pressure catheters in brain ventricles. The amplitude of central retinal vein pulsations (RVPa) has been shown to be associated with the pressure gradient between intraocular pressure (IOP) and ICP. When IOP approaches ICP, the pressure gradient drops, leading to cessation of RVPa. In this study we aim to investigate this relationship and define a new method to estimate ICP non-invasively. 10 healthy subjects (mean age 35±10) with clear medical history were included in this study. Baseline IOP was measured (Goldman tonometers) and RVP recorded using Dynamic Vessel Analyser.IOP was decreased actively using 0.5% Iopidine and RVP recorded simultaneously every 15 minutes. Digital signal processing techniques were used to measure mean RVP peak-to-peak amplitude in each cardiac cycle at different IOP levels. Linear regression equations were used to extract a relation between IOP and RVPa and to estimate the pressure at which RVPa cease (i.e. RVPa=0). At this point ICP equals IOP. IOP and ICP pressure waveforms were simulated in order to estimate ICP continuously. Results show a linear relationship between RVPa and IOP such that RVP decreases with IOP reduction. Estimated ICP ranged between 2-13.7 mmHg, all falling in the normal physiological range (i.e. 0-15 mmHg). Analysis of retinal venous pulsation in accordance with IOP may introduce a novel approach for estimation of ICP non-invasively.

Original language	English
Title of host publication	26th Southern Biomedical Engineering Conference SBEC 2010
Editors	Keith E. Herold, William E. Bentley, Jafar Vossoughi
Place of Publication	Berlin
Publisher	Springer, Springer Nature
Pages	81-84
Number of pages	4
Volume	32 IFMBE
ISBN (Print)	9783642149979, 3642149979
DOIs	https://doi.org/10.1007/978-3-642-14998-6_22
Publication status	Published - 2010
Event	26th Southern Biomedical Engineering Conference, SBEC 2010 - College Park, MD, United States Duration: 30 Apr 2010 → 2 May 2010

Other

Other	26th Southern Biomedical Engineering Conference, SBEC 2010
Country/Territory	United States
City	College Park, MD
Period	30/04/10 → 2/05/10

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10.1007/978-3-642-14998-6_22

Cite this

@inproceedings{445b80abdeb14abcbffd59133c673ed5,

title = "Non-invasive estimation of intracranial pressure by means of retinal venous pulsatility",

abstract = "Current techniques used to measure intracranial pressure (ICP) are invasive and require surgical procedures in order to implant pressure catheters in brain ventricles. The amplitude of central retinal vein pulsations (RVPa) has been shown to be associated with the pressure gradient between intraocular pressure (IOP) and ICP. When IOP approaches ICP, the pressure gradient drops, leading to cessation of RVPa. In this study we aim to investigate this relationship and define a new method to estimate ICP non-invasively. 10 healthy subjects (mean age 35±10) with clear medical history were included in this study. Baseline IOP was measured (Goldman tonometers) and RVP recorded using Dynamic Vessel Analyser.IOP was decreased actively using 0.5% Iopidine and RVP recorded simultaneously every 15 minutes. Digital signal processing techniques were used to measure mean RVP peak-to-peak amplitude in each cardiac cycle at different IOP levels. Linear regression equations were used to extract a relation between IOP and RVPa and to estimate the pressure at which RVPa cease (i.e. RVPa=0). At this point ICP equals IOP. IOP and ICP pressure waveforms were simulated in order to estimate ICP continuously. Results show a linear relationship between RVPa and IOP such that RVP decreases with IOP reduction. Estimated ICP ranged between 2-13.7 mmHg, all falling in the normal physiological range (i.e. 0-15 mmHg). Analysis of retinal venous pulsation in accordance with IOP may introduce a novel approach for estimation of ICP non-invasively.",

author = "Golzan, {S. Mojtaba} and Graham, {Stuart L.} and Alberto Avolio",

year = "2010",

doi = "10.1007/978-3-642-14998-6_22",

language = "English",

isbn = "9783642149979",

volume = "32 IFMBE",

pages = "81--84",

editor = "Herold, {Keith E.} and Bentley, {William E.} and Jafar Vossoughi",

booktitle = "26th Southern Biomedical Engineering Conference SBEC 2010",

publisher = "Springer, Springer Nature",

address = "United States",

note = "26th Southern Biomedical Engineering Conference, SBEC 2010 ; Conference date: 30-04-2010 Through 02-05-2010",

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Golzan, SM, Graham, SL & Avolio, A 2010, Non-invasive estimation of intracranial pressure by means of retinal venous pulsatility. in KE Herold, WE Bentley & J Vossoughi (eds), 26th Southern Biomedical Engineering Conference SBEC 2010. vol. 32 IFMBE, Springer, Springer Nature, Berlin, pp. 81-84, 26th Southern Biomedical Engineering Conference, SBEC 2010, College Park, MD, United States, 30/04/10. https://doi.org/10.1007/978-3-642-14998-6_22

Non-invasive estimation of intracranial pressure by means of retinal venous pulsatility. / Golzan, S. Mojtaba; Graham, Stuart L.; Avolio, Alberto.

26th Southern Biomedical Engineering Conference SBEC 2010. ed. / Keith E. Herold; William E. Bentley; Jafar Vossoughi. Vol. 32 IFMBE Berlin : Springer, Springer Nature, 2010. p. 81-84.

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review

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T1 - Non-invasive estimation of intracranial pressure by means of retinal venous pulsatility

AU - Golzan, S. Mojtaba

AU - Graham, Stuart L.

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N2 - Current techniques used to measure intracranial pressure (ICP) are invasive and require surgical procedures in order to implant pressure catheters in brain ventricles. The amplitude of central retinal vein pulsations (RVPa) has been shown to be associated with the pressure gradient between intraocular pressure (IOP) and ICP. When IOP approaches ICP, the pressure gradient drops, leading to cessation of RVPa. In this study we aim to investigate this relationship and define a new method to estimate ICP non-invasively. 10 healthy subjects (mean age 35±10) with clear medical history were included in this study. Baseline IOP was measured (Goldman tonometers) and RVP recorded using Dynamic Vessel Analyser.IOP was decreased actively using 0.5% Iopidine and RVP recorded simultaneously every 15 minutes. Digital signal processing techniques were used to measure mean RVP peak-to-peak amplitude in each cardiac cycle at different IOP levels. Linear regression equations were used to extract a relation between IOP and RVPa and to estimate the pressure at which RVPa cease (i.e. RVPa=0). At this point ICP equals IOP. IOP and ICP pressure waveforms were simulated in order to estimate ICP continuously. Results show a linear relationship between RVPa and IOP such that RVP decreases with IOP reduction. Estimated ICP ranged between 2-13.7 mmHg, all falling in the normal physiological range (i.e. 0-15 mmHg). Analysis of retinal venous pulsation in accordance with IOP may introduce a novel approach for estimation of ICP non-invasively.

AB - Current techniques used to measure intracranial pressure (ICP) are invasive and require surgical procedures in order to implant pressure catheters in brain ventricles. The amplitude of central retinal vein pulsations (RVPa) has been shown to be associated with the pressure gradient between intraocular pressure (IOP) and ICP. When IOP approaches ICP, the pressure gradient drops, leading to cessation of RVPa. In this study we aim to investigate this relationship and define a new method to estimate ICP non-invasively. 10 healthy subjects (mean age 35±10) with clear medical history were included in this study. Baseline IOP was measured (Goldman tonometers) and RVP recorded using Dynamic Vessel Analyser.IOP was decreased actively using 0.5% Iopidine and RVP recorded simultaneously every 15 minutes. Digital signal processing techniques were used to measure mean RVP peak-to-peak amplitude in each cardiac cycle at different IOP levels. Linear regression equations were used to extract a relation between IOP and RVPa and to estimate the pressure at which RVPa cease (i.e. RVPa=0). At this point ICP equals IOP. IOP and ICP pressure waveforms were simulated in order to estimate ICP continuously. Results show a linear relationship between RVPa and IOP such that RVP decreases with IOP reduction. Estimated ICP ranged between 2-13.7 mmHg, all falling in the normal physiological range (i.e. 0-15 mmHg). Analysis of retinal venous pulsation in accordance with IOP may introduce a novel approach for estimation of ICP non-invasively.

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SN - 3642149979

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BT - 26th Southern Biomedical Engineering Conference SBEC 2010

A2 - Herold, Keith E.

A2 - Bentley, William E.

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PB - Springer, Springer Nature

CY - Berlin

T2 - 26th Southern Biomedical Engineering Conference, SBEC 2010

Y2 - 30 April 2010 through 2 May 2010

ER -

Non-invasive estimation of intracranial pressure by means of retinal venous pulsatility

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