Non-symmetrical double-logistic analysis of 24 hour arterial stiffness profile in normotensive and hypertensive subjects

D. Bia; R. Armentano; F. Pessana; Y. Zócalo; S. Lluberas; A. P. Avolio

Non-symmetrical double-logistic analysis of 24 hour arterial stiffness profile in normotensive and hypertensive subjects

D. Bia^*, R. Armentano, F. Pessana, Y. Zócalo, S. Lluberas, A. P. Avolio

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review

6 Citations (Scopus)

Abstract

Objectives: Mechanisms underlying the circadian profile of cardiovascular events (CE) are not totally understood. Whether circadian changes in arterial stiffness (AS) could be related to the circadian profile of CE remains to be investigated. As yet, there is no accepted way to measure circadian profiles or nocturnal-related and/or morning-related changes in cardiovascular variables. The aim of this study was to characterize the circadian pattern and day-night and nightday changes of AS in untreated hypertensive (HG) and healthy subjects (NG), using a recently developed non-symmetrical sixparameter double-logistic model. Methods: Seven hypertensive and seven normotensive subjects underwent 24 hour ambulatory recordings of blood pressure (BP), heart rate (HR) and aorto-brachial pulse transit time (PTT_ab) and pulse transit velocity index (PTV_ab). PTT_ab and PTV_ab are inversely and directly related to AS, respectively. The circadian profile and transitional periods (day-night and night-day) were analyzed using a model described by a six-parameter double logistic equation. Conclusions: The model was adequate to characterize the circadian pattern of AS. We provide the first evidence that AS in humans follows an asymmetric circadian pattern and that this differs between NG and HG. In both NG and HG, AS had a circadian profile, with the highest levels in the night. HG showed larger levels of AS, larger BP variations and rate of change and minor changes in AS during transitional periods.

Original language	English
Title of host publication	Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
Place of Publication	Piscataway, NJ
Publisher	Institute of Electrical and Electronics Engineers (IEEE)
Pages	809-812
Number of pages	4
ISBN (Print)	9781424418152
Publication status	Published - 2008
Event	30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - Vancouver, BC, Canada Duration: 20 Aug 2008 → 25 Aug 2008

Other

Other	30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
Country/Territory	Canada
City	Vancouver, BC
Period	20/08/08 → 25/08/08

Cite this

Bia, D., Armentano, R., Pessana, F., Zócalo, Y., Lluberas, S., & Avolio, A. P. (2008). Non-symmetrical double-logistic analysis of 24 hour arterial stiffness profile in normotensive and hypertensive subjects. In Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 (pp. 809-812). Article 4649277 Institute of Electrical and Electronics Engineers (IEEE).

Bia, D. ; Armentano, R. ; Pessana, F. et al. / Non-symmetrical double-logistic analysis of 24 hour arterial stiffness profile in normotensive and hypertensive subjects. Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08. Piscataway, NJ : Institute of Electrical and Electronics Engineers (IEEE), 2008. pp. 809-812

@inproceedings{67125f8f96484e2b98deb857a57d743f,

title = "Non-symmetrical double-logistic analysis of 24 hour arterial stiffness profile in normotensive and hypertensive subjects",

abstract = "Objectives: Mechanisms underlying the circadian profile of cardiovascular events (CE) are not totally understood. Whether circadian changes in arterial stiffness (AS) could be related to the circadian profile of CE remains to be investigated. As yet, there is no accepted way to measure circadian profiles or nocturnal-related and/or morning-related changes in cardiovascular variables. The aim of this study was to characterize the circadian pattern and day-night and nightday changes of AS in untreated hypertensive (HG) and healthy subjects (NG), using a recently developed non-symmetrical sixparameter double-logistic model. Methods: Seven hypertensive and seven normotensive subjects underwent 24 hour ambulatory recordings of blood pressure (BP), heart rate (HR) and aorto-brachial pulse transit time (PTTab) and pulse transit velocity index (PTVab). PTTab and PTVab are inversely and directly related to AS, respectively. The circadian profile and transitional periods (day-night and night-day) were analyzed using a model described by a six-parameter double logistic equation. Conclusions: The model was adequate to characterize the circadian pattern of AS. We provide the first evidence that AS in humans follows an asymmetric circadian pattern and that this differs between NG and HG. In both NG and HG, AS had a circadian profile, with the highest levels in the night. HG showed larger levels of AS, larger BP variations and rate of change and minor changes in AS during transitional periods. ",

author = "D. Bia and R. Armentano and F. Pessana and Y. Z{\'o}calo and S. Lluberas and Avolio, {A. P.}",

year = "2008",

language = "English",

isbn = "9781424418152",

pages = "809--812",

booktitle = "Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08",

publisher = "Institute of Electrical and Electronics Engineers (IEEE)",

address = "United States",

note = "30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 ; Conference date: 20-08-2008 Through 25-08-2008",

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Bia, D, Armentano, R, Pessana, F, Zócalo, Y, Lluberas, S & Avolio, AP 2008, Non-symmetrical double-logistic analysis of 24 hour arterial stiffness profile in normotensive and hypertensive subjects. in Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08., 4649277, Institute of Electrical and Electronics Engineers (IEEE), Piscataway, NJ, pp. 809-812, 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08, Vancouver, BC, Canada, 20/08/08.

Non-symmetrical double-logistic analysis of 24 hour arterial stiffness profile in normotensive and hypertensive subjects. / Bia, D.; Armentano, R.; Pessana, F. et al.
Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08. Piscataway, NJ: Institute of Electrical and Electronics Engineers (IEEE), 2008. p. 809-812 4649277.

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review

TY - GEN

T1 - Non-symmetrical double-logistic analysis of 24 hour arterial stiffness profile in normotensive and hypertensive subjects

AU - Bia, D.

AU - Armentano, R.

AU - Pessana, F.

AU - Zócalo, Y.

AU - Lluberas, S.

AU - Avolio, A. P.

PY - 2008

Y1 - 2008

N2 - Objectives: Mechanisms underlying the circadian profile of cardiovascular events (CE) are not totally understood. Whether circadian changes in arterial stiffness (AS) could be related to the circadian profile of CE remains to be investigated. As yet, there is no accepted way to measure circadian profiles or nocturnal-related and/or morning-related changes in cardiovascular variables. The aim of this study was to characterize the circadian pattern and day-night and nightday changes of AS in untreated hypertensive (HG) and healthy subjects (NG), using a recently developed non-symmetrical sixparameter double-logistic model. Methods: Seven hypertensive and seven normotensive subjects underwent 24 hour ambulatory recordings of blood pressure (BP), heart rate (HR) and aorto-brachial pulse transit time (PTTab) and pulse transit velocity index (PTVab). PTTab and PTVab are inversely and directly related to AS, respectively. The circadian profile and transitional periods (day-night and night-day) were analyzed using a model described by a six-parameter double logistic equation. Conclusions: The model was adequate to characterize the circadian pattern of AS. We provide the first evidence that AS in humans follows an asymmetric circadian pattern and that this differs between NG and HG. In both NG and HG, AS had a circadian profile, with the highest levels in the night. HG showed larger levels of AS, larger BP variations and rate of change and minor changes in AS during transitional periods.

AB - Objectives: Mechanisms underlying the circadian profile of cardiovascular events (CE) are not totally understood. Whether circadian changes in arterial stiffness (AS) could be related to the circadian profile of CE remains to be investigated. As yet, there is no accepted way to measure circadian profiles or nocturnal-related and/or morning-related changes in cardiovascular variables. The aim of this study was to characterize the circadian pattern and day-night and nightday changes of AS in untreated hypertensive (HG) and healthy subjects (NG), using a recently developed non-symmetrical sixparameter double-logistic model. Methods: Seven hypertensive and seven normotensive subjects underwent 24 hour ambulatory recordings of blood pressure (BP), heart rate (HR) and aorto-brachial pulse transit time (PTTab) and pulse transit velocity index (PTVab). PTTab and PTVab are inversely and directly related to AS, respectively. The circadian profile and transitional periods (day-night and night-day) were analyzed using a model described by a six-parameter double logistic equation. Conclusions: The model was adequate to characterize the circadian pattern of AS. We provide the first evidence that AS in humans follows an asymmetric circadian pattern and that this differs between NG and HG. In both NG and HG, AS had a circadian profile, with the highest levels in the night. HG showed larger levels of AS, larger BP variations and rate of change and minor changes in AS during transitional periods.

UR - http://www.scopus.com/inward/record.url?scp=84903874423&partnerID=8YFLogxK

M3 - Conference proceeding contribution

C2 - 19162780

AN - SCOPUS:61849124073

SN - 9781424418152

SP - 809

EP - 812

BT - Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08

PB - Institute of Electrical and Electronics Engineers (IEEE)

CY - Piscataway, NJ

T2 - 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08

Y2 - 20 August 2008 through 25 August 2008

ER -

Bia D, Armentano R, Pessana F, Zócalo Y, Lluberas S, Avolio AP. Non-symmetrical double-logistic analysis of 24 hour arterial stiffness profile in normotensive and hypertensive subjects. In Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08. Piscataway, NJ: Institute of Electrical and Electronics Engineers (IEEE). 2008. p. 809-812. 4649277

Non-symmetrical double-logistic analysis of 24 hour arterial stiffness profile in normotensive and hypertensive subjects

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