Noncovalent self-assembled smart gold(III) porphyrin nanodrug for synergistic chemo-photothermal therapy

Xiao Wang; Jiefei Wang; Jinghan Wang; Yong Zhong; Lulu Han; Jiliang Yan; Pengcheng Duan; Bingyang Shi; Feng Bai

doi:10.1021/acs.nanolett.0c04915

Noncovalent self-assembled smart gold(III) porphyrin nanodrug for synergistic chemo-photothermal therapy

Xiao Wang, Jiefei Wang, Jinghan Wang, Yong Zhong, Lulu Han, Jiliang Yan, Pengcheng Duan, Bingyang Shi, Feng Bai^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Self-assembly is a powerful means to fabricate multifunctional smart nanotheranostics. However, the complicated preparation, toxicity of responsive carriers, and low loading efficiency of drug cargo hinder the outcome. Herein, we developed a responsive carrier-free noncovalent self-assembly strategy of a metallized Au(III) tetra-(4-pyridyl) porphine (AuTPyP) anticancer drug for the preparation of a heat/acid dual-stimulated nanodrug, and it generated a better photothermal effect than monomers under irradiation. The photothermal effect promoted the protonation of the hydrophobic pyridyl group and the following release into tumorous acidic microenvironments. With cRGD modification, the released drug induced the aggravation of intracellular reactive oxygen species (ROS) via the activity inhibition of thioredoxin reductase (TrxR) for synergistic chemo-photothermal therapy of tumors.

Original language	English
Pages (from-to)	3418-3425
Number of pages	8
Journal	Nano Letters
Volume	21
Issue number	8
DOIs	https://doi.org/10.1021/acs.nanolett.0c04915
Publication status	Published - 28 Apr 2021

Keywords

dual stimuli
gold porphyrin
metalation
self-assembly
synergistic therapy

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10.1021/acs.nanolett.0c04915

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title = "Noncovalent self-assembled smart gold(III) porphyrin nanodrug for synergistic chemo-photothermal therapy",

abstract = "Self-assembly is a powerful means to fabricate multifunctional smart nanotheranostics. However, the complicated preparation, toxicity of responsive carriers, and low loading efficiency of drug cargo hinder the outcome. Herein, we developed a responsive carrier-free noncovalent self-assembly strategy of a metallized Au(III) tetra-(4-pyridyl) porphine (AuTPyP) anticancer drug for the preparation of a heat/acid dual-stimulated nanodrug, and it generated a better photothermal effect than monomers under irradiation. The photothermal effect promoted the protonation of the hydrophobic pyridyl group and the following release into tumorous acidic microenvironments. With cRGD modification, the released drug induced the aggravation of intracellular reactive oxygen species (ROS) via the activity inhibition of thioredoxin reductase (TrxR) for synergistic chemo-photothermal therapy of tumors. ",

keywords = "dual stimuli, gold porphyrin, metalation, self-assembly, synergistic therapy",

author = "Xiao Wang and Jiefei Wang and Jinghan Wang and Yong Zhong and Lulu Han and Jiliang Yan and Pengcheng Duan and Bingyang Shi and Feng Bai",

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doi = "10.1021/acs.nanolett.0c04915",

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T1 - Noncovalent self-assembled smart gold(III) porphyrin nanodrug for synergistic chemo-photothermal therapy

AU - Wang, Xiao

AU - Wang, Jiefei

AU - Wang, Jinghan

AU - Zhong, Yong

AU - Han, Lulu

AU - Yan, Jiliang

AU - Duan, Pengcheng

AU - Shi, Bingyang

AU - Bai, Feng

PY - 2021/4/28

Y1 - 2021/4/28

N2 - Self-assembly is a powerful means to fabricate multifunctional smart nanotheranostics. However, the complicated preparation, toxicity of responsive carriers, and low loading efficiency of drug cargo hinder the outcome. Herein, we developed a responsive carrier-free noncovalent self-assembly strategy of a metallized Au(III) tetra-(4-pyridyl) porphine (AuTPyP) anticancer drug for the preparation of a heat/acid dual-stimulated nanodrug, and it generated a better photothermal effect than monomers under irradiation. The photothermal effect promoted the protonation of the hydrophobic pyridyl group and the following release into tumorous acidic microenvironments. With cRGD modification, the released drug induced the aggravation of intracellular reactive oxygen species (ROS) via the activity inhibition of thioredoxin reductase (TrxR) for synergistic chemo-photothermal therapy of tumors.

AB - Self-assembly is a powerful means to fabricate multifunctional smart nanotheranostics. However, the complicated preparation, toxicity of responsive carriers, and low loading efficiency of drug cargo hinder the outcome. Herein, we developed a responsive carrier-free noncovalent self-assembly strategy of a metallized Au(III) tetra-(4-pyridyl) porphine (AuTPyP) anticancer drug for the preparation of a heat/acid dual-stimulated nanodrug, and it generated a better photothermal effect than monomers under irradiation. The photothermal effect promoted the protonation of the hydrophobic pyridyl group and the following release into tumorous acidic microenvironments. With cRGD modification, the released drug induced the aggravation of intracellular reactive oxygen species (ROS) via the activity inhibition of thioredoxin reductase (TrxR) for synergistic chemo-photothermal therapy of tumors.

KW - dual stimuli

KW - gold porphyrin

KW - metalation

KW - self-assembly

KW - synergistic therapy

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JO - Nano Letters

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IS - 8

ER -

Noncovalent self-assembled smart gold(III) porphyrin nanodrug for synergistic chemo-photothermal therapy

Abstract

Keywords

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