Nonlinkage of D6S260, a Putative Schizophrenia Locus, to Bipolar Affective Disorder

Linda J. Adams, Judy Salmon, Jennifer A. Donald, Philip B. Mitchell, Peter R. Schofield*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

To examine whether genes that predispose to schizophrenia also confer a predisposition to other psychiatric disorders such as bipolar affective disorder (BAD), we tested for linkage between the recently identified schizophrenia susceptibility locus D6S260 and the inheritance of BAD in 12 large Australian pedigrees. We found no evidence for linkage over a region of 12-27 cM from the D6S260 locus, depending on the model used. Our results therefore do not provide support for the continuum theory of psychosis.

Original languageEnglish
Pages (from-to)485-487
Number of pages3
JournalAmerican Journal of Medical Genetics - Seminars in Medical Genetics
Volume67
Issue number5
Publication statusPublished - 20 Sep 1996
Externally publishedYes

Keywords

  • Bipolar affective disorder
  • Genetic linkage analysis
  • Genetic predisposition
  • Human chromosome 6
  • Manic depressive illness
  • Schizophrenia

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