Nonlinkage of D6S260, a Putative Schizophrenia Locus, to Bipolar Affective Disorder

Linda J. Adams; Judy Salmon; Jennifer A. Donald; Philip B. Mitchell; Peter R. Schofield

Nonlinkage of D6S260, a Putative Schizophrenia Locus, to Bipolar Affective Disorder

Linda J. Adams, Judy Salmon, Jennifer A. Donald, Philip B. Mitchell, Peter R. Schofield^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

To examine whether genes that predispose to schizophrenia also confer a predisposition to other psychiatric disorders such as bipolar affective disorder (BAD), we tested for linkage between the recently identified schizophrenia susceptibility locus D6S260 and the inheritance of BAD in 12 large Australian pedigrees. We found no evidence for linkage over a region of 12-27 cM from the D6S260 locus, depending on the model used. Our results therefore do not provide support for the continuum theory of psychosis.

Original language	English
Pages (from-to)	485-487
Number of pages	3
Journal	American Journal of Medical Genetics - Seminars in Medical Genetics
Volume	67
Issue number	5
Publication status	Published - 20 Sept 1996
Externally published	Yes

Keywords

Bipolar affective disorder
Genetic linkage analysis
Genetic predisposition
Human chromosome 6
Manic depressive illness
Schizophrenia

Cite this

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title = "Nonlinkage of D6S260, a Putative Schizophrenia Locus, to Bipolar Affective Disorder",

abstract = "To examine whether genes that predispose to schizophrenia also confer a predisposition to other psychiatric disorders such as bipolar affective disorder (BAD), we tested for linkage between the recently identified schizophrenia susceptibility locus D6S260 and the inheritance of BAD in 12 large Australian pedigrees. We found no evidence for linkage over a region of 12-27 cM from the D6S260 locus, depending on the model used. Our results therefore do not provide support for the continuum theory of psychosis.",

keywords = "Bipolar affective disorder, Genetic linkage analysis, Genetic predisposition, Human chromosome 6, Manic depressive illness, Schizophrenia",

author = "Adams, {Linda J.} and Judy Salmon and Donald, {Jennifer A.} and Mitchell, {Philip B.} and Schofield, {Peter R.}",

year = "1996",

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AU - Adams, Linda J.

AU - Salmon, Judy

AU - Donald, Jennifer A.

AU - Mitchell, Philip B.

AU - Schofield, Peter R.

PY - 1996/9/20

Y1 - 1996/9/20

N2 - To examine whether genes that predispose to schizophrenia also confer a predisposition to other psychiatric disorders such as bipolar affective disorder (BAD), we tested for linkage between the recently identified schizophrenia susceptibility locus D6S260 and the inheritance of BAD in 12 large Australian pedigrees. We found no evidence for linkage over a region of 12-27 cM from the D6S260 locus, depending on the model used. Our results therefore do not provide support for the continuum theory of psychosis.

AB - To examine whether genes that predispose to schizophrenia also confer a predisposition to other psychiatric disorders such as bipolar affective disorder (BAD), we tested for linkage between the recently identified schizophrenia susceptibility locus D6S260 and the inheritance of BAD in 12 large Australian pedigrees. We found no evidence for linkage over a region of 12-27 cM from the D6S260 locus, depending on the model used. Our results therefore do not provide support for the continuum theory of psychosis.

KW - Bipolar affective disorder

KW - Genetic linkage analysis

KW - Genetic predisposition

KW - Human chromosome 6

KW - Manic depressive illness

KW - Schizophrenia

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M3 - Article

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AN - SCOPUS:0029773842

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JO - American Journal of Medical Genetics - Seminars in Medical Genetics

JF - American Journal of Medical Genetics - Seminars in Medical Genetics

IS - 5

ER -

Nonlinkage of D6S260, a Putative Schizophrenia Locus, to Bipolar Affective Disorder

Abstract

Keywords

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