Normal vascular aging

Differential effects on wave reflection and aortic pulse wave velocity - The Anglo-Cardiff Collaborative Trial (ACCT)

Carmel M. McEniery*, Yasmin, Ian R. Hall, Ahmad Qasem, Ian B. Wilkinson, John R. Cockcroft

*Corresponding author for this work

Research output: Contribution to journalArticle

875 Citations (Scopus)

Abstract

OBJECTIVES: The aim of the current investigation was to test the hypothesis that age-related changes in augmentation index (AIx) are more prominent in younger individuals (<50 years), whereas changes in aortic stiffness per se are more marked in older individuals (>50 years). BACKGROUND: Aging exerts a number of deleterious changes in the cardiovascular system, and, in particular, on the large arteries. Previous studies have suggested that AIx and pulse wave velocity (PWV) increase linearly with age, yet epidemiological data concerning pulse pressure suggest that large artery stiffening predominantly occurs later in life. METHODS: Peripheral and central blood pressure, augmentation pressure (AP), and AIx were determined in 4,001 healthy, normotensive individuals, aged 18 to 90 years. Aortic and brachial PWV were also determined in a subset of 998 subjects. RESULTS: Peripheral and central pulse pressure, AP, AIx, and aortic and brachial PWV all increased significantly with age; however, the age-related changes in AIx and aortic PWV were non-linear, with AIx increasing more in younger individuals, whereas the changes in PWV were more prominent in older individuals. CONCLUSIONS: These data suggest that AIx might be a more sensitive marker of arterial stiffening and risk in younger individuals but aortic PWV is likely to be a better measure in older individuals.

Original languageEnglish
Pages (from-to)1753-1760
Number of pages8
JournalJournal of the American College of Cardiology
Volume46
Issue number9
DOIs
Publication statusPublished - 1 Nov 2005
Externally publishedYes

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