Note: The upside of downsizing: Asymmetric trifunctional organocatalysts as small enzyme mimics for cooperative enhancement of both rate and enantioselectivity with regulation

Fei Liu*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Small molecule organic catalysts (organocatalysts) are widely used in asymmetric catalysis and synthesis. Compared to their enzymatic and transition-metal counterparts, organocatalysts have advantages in catalytic scope and efficiency but are more limited in proficiency. Chiral trifunctional organocatalysts, in whichmultiple catalyticmotifs act cooperatively on a chiral scaffold, are an emerging class of organocatalysts with improved proficiency. Cooperativity design that enables both enantioselectivity and rate enhancement is essential to developing future generations of organocatalysts in biomimetic asymmetric catalysis.

Original languageEnglish
Pages (from-to)675-683
Number of pages8
JournalChirality
Volume26
Issue number2
DOIs
Publication statusPublished - Feb 2014

Keywords

  • catalytic assembly
  • catalytic proficiency
  • enantioselective activation
  • multifunctional organocatalysts
  • organocatalysis regulation
  • proton transfer
  • REAP factor

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