TY - JOUR
T1 - Novel antibacterial Cu/Mg-substituted 58S-bioglass
T2 - synthesis, characterization and investigation of in vitro bioactivity
AU - Moghanian, Amirhossein
AU - Ghorbanoghli, Alireza
AU - Kazem-Rostami, Masoud
AU - Pazhouheshgar, Arang
AU - Salari, Emad
AU - Yazdi, Morteza Saghafi
AU - Alimardani, Tannaz
AU - Jahani, Hossein
AU - Jazi, Fariborz Sharifian
AU - Tahriri, Mohammadreza
PY - 2020/10
Y1 - 2020/10
N2 - In this study, six sol-gel copper/magnesium substituted derivatives of 58S-BG, that is, a mol% series of 60SiO2-4P2O2-5CuO-(31-x) CaO/xMgO (where x = 0, 1, 3, 5, 8, and 10), were synthesized as new multifunctional bioactive glasses (BGs). Afterwards, the effect of MgO/CaO substitution on the in vitro formation of nanohydroxyapatite (HA), osteoblast-like cell responses, and bioactive glasses antibacterial performance were studied. X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM) results revealed that Cu-substituted 58S-BG consisting of 5 mol% MgO (BG-5/5) had capability of the formation of HA on its surface while, Cu-substituted 58S-BGs consisting 8 mol% and 10 mol% MgO (BG-5/8 and BG-5/10) displayed lower bioactivity. The In vitro investigations proved that the highest values of both differentiation and proliferation of MC3T3-E1 cells can be obtained from a 5 mol% MgO substituted BG. Furthermore, these novel Cu/Mg-substituted 58S-BGs displayed antibacterial effect against methicillin-resistant staphylococcus aureus bacteria. Taken together, the results suggest the equally substituted BG-5/5 (ie., the one consists of 5 mol% of both CuO and MgO) as a promising candidate for bone tissue engineering, among all newly designed BGs in this work, owing to its desirable cell proliferation, ALP activity, and antibacterial properties.
AB - In this study, six sol-gel copper/magnesium substituted derivatives of 58S-BG, that is, a mol% series of 60SiO2-4P2O2-5CuO-(31-x) CaO/xMgO (where x = 0, 1, 3, 5, 8, and 10), were synthesized as new multifunctional bioactive glasses (BGs). Afterwards, the effect of MgO/CaO substitution on the in vitro formation of nanohydroxyapatite (HA), osteoblast-like cell responses, and bioactive glasses antibacterial performance were studied. X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM) results revealed that Cu-substituted 58S-BG consisting of 5 mol% MgO (BG-5/5) had capability of the formation of HA on its surface while, Cu-substituted 58S-BGs consisting 8 mol% and 10 mol% MgO (BG-5/8 and BG-5/10) displayed lower bioactivity. The In vitro investigations proved that the highest values of both differentiation and proliferation of MC3T3-E1 cells can be obtained from a 5 mol% MgO substituted BG. Furthermore, these novel Cu/Mg-substituted 58S-BGs displayed antibacterial effect against methicillin-resistant staphylococcus aureus bacteria. Taken together, the results suggest the equally substituted BG-5/5 (ie., the one consists of 5 mol% of both CuO and MgO) as a promising candidate for bone tissue engineering, among all newly designed BGs in this work, owing to its desirable cell proliferation, ALP activity, and antibacterial properties.
KW - bioactivity
KW - biomedical applications
KW - characterization
KW - hydroxyapatite
KW - MgO
KW - sol-gel processes
UR - http://www.scopus.com/inward/record.url?scp=85076162606&partnerID=8YFLogxK
U2 - 10.1111/ijag.14510
DO - 10.1111/ijag.14510
M3 - Article
VL - 11
SP - 685
EP - 698
JO - International Journal of Applied Glass Science
JF - International Journal of Applied Glass Science
SN - 2041-1286
IS - 4
ER -