Novel imaging tools for investigating the role of immune signalling in the brain

Jonathan Henry W Jacobsen, Lindsay M. Parker, Arun V. Everest-Dass, Erik P. Schartner, Georgios Tsiminis, Vasiliki Staikopoulos, Mark R. Hutchinson, Sanam Mustafa*

*Corresponding author for this work

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The importance of neuro-immune interactions in both physiological and pathophysiological states cannot be overstated. As our appreciation for the neuroimmune nature of the brain and spinal cord grows, so does our need to extend the spatial and temporal resolution of our molecular analysis techniques. Current imaging technologies applied to investigate the actions of the neuroimmune system in both health and disease states have been adapted from the fields of immunology and neuroscience. While these classical techniques have provided immense insight into the function of the CNS, they are however, inherently limited. Thus, the development of innovative methods which overcome these limitations are crucial for imaging and quantifying acute and chronic neuroimmune responses. Therefore, this review aims to convey emerging novel and complementary imaging technologies in a form accessible to medical scientists engaging in neuroimmune research.

Original languageEnglish
Pages (from-to)40-47
Number of pages8
JournalBrain, Behavior, and Immunity
Volume58
DOIs
Publication statusPublished - 1 Nov 2016

Keywords

  • neuroinflammation
  • immune signalling
  • immunohistochemistry
  • tissue clearing
  • nanoparticles
  • RNA-based probes
  • MALDI imaging
  • Raman spectroscopy
  • imaging tools

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