Novel indole-isoxazole hybrids: synthesis and in vitro anti-cholinesterase activity

Fahimeh Vafadarnejad, Mina Saeedi, Mohammad Mahdavi, Ali Rafinejad, Elahe Karimpour-Razkenari, Bilqees Sameem, Mahnaz Khanavi, Tahmineh Akbarzadeh*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Background: This work reports synthesis and in vitro cholinesterase inhibitory activity of novel indole-isoxazole hybrids.

Method: The synthetic procedure was started from different ethyl 5-Arylisoxazole-3-carboxylate derivatives. Hydrolysis and reaction of the later compound with tryptamine afforded the desired products in good yields.

Conclusion: Among the synthesized compounds, N-(2-(1H-indol-3-yl)ethyl)-5-(2-chlorophenyl) isoxazole-3-carboxamide (4b) showed the best anti-cholinesterase activity.

Original languageEnglish
Pages (from-to)712-717
Number of pages6
JournalLetters in Drug Design and Discovery
Issue number6
Publication statusPublished - 2017
Externally publishedYes


  • Acetylcholinesterase
  • Alzheimer's disease
  • Butyrylcholinesterase
  • Heterocycles
  • Indole
  • Isoxazole


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