TY - JOUR
T1 - Novel indole-isoxazole hybrids
T2 - synthesis and in vitro anti-cholinesterase activity
AU - Vafadarnejad, Fahimeh
AU - Saeedi, Mina
AU - Mahdavi, Mohammad
AU - Rafinejad, Ali
AU - Karimpour-Razkenari, Elahe
AU - Sameem, Bilqees
AU - Khanavi, Mahnaz
AU - Akbarzadeh, Tahmineh
PY - 2017
Y1 - 2017
N2 - Background: This work reports synthesis and in vitro cholinesterase inhibitory activity of novel indole-isoxazole hybrids. Method: The synthetic procedure was started from different ethyl 5-Arylisoxazole-3-carboxylate derivatives. Hydrolysis and reaction of the later compound with tryptamine afforded the desired products in good yields. Conclusion: Among the synthesized compounds, N-(2-(1H-indol-3-yl)ethyl)-5-(2-chlorophenyl) isoxazole-3-carboxamide (4b) showed the best anti-cholinesterase activity.
AB - Background: This work reports synthesis and in vitro cholinesterase inhibitory activity of novel indole-isoxazole hybrids. Method: The synthetic procedure was started from different ethyl 5-Arylisoxazole-3-carboxylate derivatives. Hydrolysis and reaction of the later compound with tryptamine afforded the desired products in good yields. Conclusion: Among the synthesized compounds, N-(2-(1H-indol-3-yl)ethyl)-5-(2-chlorophenyl) isoxazole-3-carboxamide (4b) showed the best anti-cholinesterase activity.
KW - Acetylcholinesterase
KW - Alzheimer's disease
KW - Butyrylcholinesterase
KW - Heterocycles
KW - Indole
KW - Isoxazole
UR - http://www.scopus.com/inward/record.url?scp=85022218777&partnerID=8YFLogxK
U2 - 10.2174/1570180813666161018124726
DO - 10.2174/1570180813666161018124726
M3 - Article
AN - SCOPUS:85022218777
VL - 14
SP - 712
EP - 717
JO - Letters in Drug Design and Discovery
JF - Letters in Drug Design and Discovery
SN - 1570-1808
IS - 6
ER -