Novel nanostructured lipid carriers as a promising food grade delivery system for rutin

Afshin Babazadeh, Babak Ghanbarzadeh, Hamed Hamishehkar

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)


The aim of the present study was to encapsulate rutin by nanostructured lipid carriers (R-NLCs), as a solution to eliminate the fortification difficulties and provide healthier functional foods. Rutin was loaded into food grade NLCs in different rutin to lipid ratios using high shear rate homogenization method. Colloidal properties of R-NLCs such as particle size, poly dispersity index, encapsulation efficiency, loading capacity, and encapsulation stability were studied. R-NLCs with a rutin to lipid ratio of 10% were selected as an optimum formulation. Morphological studies have shown that R-NLCs are round shaped particles with smooth surfaces. The R-NLC fortified food samples and models were subjected to pH, physical and thermal stability, and turbidity analysis. The results indicated that the developed R-NLCs could provide a method for designing new functional foods based on nanocarriers.
Original languageEnglish
Pages (from-to)167-175
Number of pages9
JournalJournal of Functional Foods
Publication statusPublished - Oct 2016
Externally publishedYes


  • fortification
  • nanostructured lipid carrier
  • NLC
  • Nutraceutical
  • Rutin


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