Novel roles for protein disulphide isomerase in disease states: a double edged sword?

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    Abstract

    Protein disulphide isomerase (PDI) is a multifunctional redox chaperone of the endoplasmic reticulum (ER). Since it was first discovered 40 years ago the functions ascribed to PDI have evolved significantly and recent studies have recognized its distinct functions, with adverse as well as protective effects in disease. Furthermore, post translational modifications of PDI abrogate its normal functional roles in specific disease states. This review focusses on recent studies that have identified novel functions for PDI relevant to specific diseases.

    Original languageEnglish
    Article number30
    Pages (from-to)1-11
    Number of pages11
    JournalFrontiers in Cell and Developmental Biology
    Volume3
    DOIs
    Publication statusPublished - 2015

    Bibliographical note

    Copyright the Author(s) 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

    Keywords

    • Amyotrophic lateral sclerosis
    • Cancer
    • Neurodegnerative diseases
    • Post-translational modifications
    • Protein chaperones
    • Protein disulfide isomerase family

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