Novel roles for protein disulphide isomerase in disease states: a double edged sword?

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Protein disulphide isomerase (PDI) is a multifunctional redox chaperone of the endoplasmic reticulum (ER). Since it was first discovered 40 years ago the functions ascribed to PDI have evolved significantly and recent studies have recognized its distinct functions, with adverse as well as protective effects in disease. Furthermore, post translational modifications of PDI abrogate its normal functional roles in specific disease states. This review focusses on recent studies that have identified novel functions for PDI relevant to specific diseases.

LanguageEnglish
Article number30
Pages1-11
Number of pages11
JournalFrontiers in cell and developmental biology
Volume3
DOIs
Publication statusPublished - 2015

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Protein Disulfide-Isomerases
Post Translational Protein Processing
Endoplasmic Reticulum
Oxidation-Reduction

Bibliographical note

Copyright the Author(s) 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Cite this

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title = "Novel roles for protein disulphide isomerase in disease states: a double edged sword?",
abstract = "Protein disulphide isomerase (PDI) is a multifunctional redox chaperone of the endoplasmic reticulum (ER). Since it was first discovered 40 years ago the functions ascribed to PDI have evolved significantly and recent studies have recognized its distinct functions, with adverse as well as protective effects in disease. Furthermore, post translational modifications of PDI abrogate its normal functional roles in specific disease states. This review focusses on recent studies that have identified novel functions for PDI relevant to specific diseases.",
author = "Sonam Parakh and Atkin, {Julie D}",
note = "Copyright the Author(s) 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",
year = "2015",
doi = "10.3389/fcell.2015.00030",
language = "English",
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pages = "1--11",
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Novel roles for protein disulphide isomerase in disease states : a double edged sword? / Parakh, Sonam; Atkin, Julie D.

In: Frontiers in cell and developmental biology, Vol. 3, 30, 2015, p. 1-11.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Novel roles for protein disulphide isomerase in disease states

T2 - Frontiers in cell and developmental biology

AU - Parakh, Sonam

AU - Atkin, Julie D

N1 - Copyright the Author(s) 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2015

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AB - Protein disulphide isomerase (PDI) is a multifunctional redox chaperone of the endoplasmic reticulum (ER). Since it was first discovered 40 years ago the functions ascribed to PDI have evolved significantly and recent studies have recognized its distinct functions, with adverse as well as protective effects in disease. Furthermore, post translational modifications of PDI abrogate its normal functional roles in specific disease states. This review focusses on recent studies that have identified novel functions for PDI relevant to specific diseases.

U2 - 10.3389/fcell.2015.00030

DO - 10.3389/fcell.2015.00030

M3 - Article

VL - 3

SP - 1

EP - 11

JO - Frontiers in cell and developmental biology

JF - Frontiers in cell and developmental biology

SN - 2296-634X

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