Novel use of polymer gels for internal radionulide dosimetry of Tc-99m

K. Braun, D. Bailey, C. Baldock

Research output: Contribution to journalMeeting abstractResearch

Abstract

Purpose: The use of polymer gels dosimeters were investigated as suitable dosimeters for assessing internal radionuclide dosimetry of Tc-99m. Material and Methods: 25-5000 MBq of Tc-99m was introduced by syringe into aqueous PAGAT polymer gel dosimeter mixtures which had been sealed in nitrogen-filled P6 glass vials. After irradiation the polymer gel dosimeters were assessed using optical spectrophotometry and MRI more than 48 hours (8 half-lives) after preparation. The dose delivered to the each P6 vial was calculated empirically and also computed using GATE Monte Carlo software. Results: Spectrophotometry optical density or MRI R2 relation rate versus total activity curves were obtained and used to evaluate the relationship between the amount of gel polymerization and the dose deposited by the radionuclide. A linear dose response was exhibited up to 1000 MBq (corresponding to 20Gy) and was still behaving monotonically at 5000 MBq. Conclusion: PAGAT polymer gel dosimeters offer the potential to measure radiation dose from Tc-99m three-dimensionally. Further work will extend these techniques to use with I-131, F-18, Y-90 and other particle emitting radionuclides.
LanguageEnglish
Pages2676-2676
Number of pages1
JournalMedical Physics
Volume35
Issue number6
DOIs
Publication statusPublished - 2008
Externally publishedYes
EventAAPM Annual Meeting (50th : 2008) - Houston, TX
Duration: 27 Jul 200831 Jul 2008

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Polymers
Gels
Radioisotopes
Spectrophotometry
Syringes
Polymerization
Glass
Nitrogen
Software
Radiation Dosimeters
Radiation

Cite this

Braun, K. ; Bailey, D. ; Baldock, C. / Novel use of polymer gels for internal radionulide dosimetry of Tc-99m. In: Medical Physics. 2008 ; Vol. 35, No. 6. pp. 2676-2676.
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title = "Novel use of polymer gels for internal radionulide dosimetry of Tc-99m",
abstract = "Purpose: The use of polymer gels dosimeters were investigated as suitable dosimeters for assessing internal radionuclide dosimetry of Tc-99m. Material and Methods: 25-5000 MBq of Tc-99m was introduced by syringe into aqueous PAGAT polymer gel dosimeter mixtures which had been sealed in nitrogen-filled P6 glass vials. After irradiation the polymer gel dosimeters were assessed using optical spectrophotometry and MRI more than 48 hours (8 half-lives) after preparation. The dose delivered to the each P6 vial was calculated empirically and also computed using GATE Monte Carlo software. Results: Spectrophotometry optical density or MRI R2 relation rate versus total activity curves were obtained and used to evaluate the relationship between the amount of gel polymerization and the dose deposited by the radionuclide. A linear dose response was exhibited up to 1000 MBq (corresponding to 20Gy) and was still behaving monotonically at 5000 MBq. Conclusion: PAGAT polymer gel dosimeters offer the potential to measure radiation dose from Tc-99m three-dimensionally. Further work will extend these techniques to use with I-131, F-18, Y-90 and other particle emitting radionuclides.",
author = "K. Braun and D. Bailey and C. Baldock",
year = "2008",
doi = "10.1118/1.2961546",
language = "English",
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Novel use of polymer gels for internal radionulide dosimetry of Tc-99m. / Braun, K.; Bailey, D.; Baldock, C.

In: Medical Physics, Vol. 35, No. 6, 2008, p. 2676-2676.

Research output: Contribution to journalMeeting abstractResearch

TY - JOUR

T1 - Novel use of polymer gels for internal radionulide dosimetry of Tc-99m

AU - Braun, K.

AU - Bailey, D.

AU - Baldock, C.

PY - 2008

Y1 - 2008

N2 - Purpose: The use of polymer gels dosimeters were investigated as suitable dosimeters for assessing internal radionuclide dosimetry of Tc-99m. Material and Methods: 25-5000 MBq of Tc-99m was introduced by syringe into aqueous PAGAT polymer gel dosimeter mixtures which had been sealed in nitrogen-filled P6 glass vials. After irradiation the polymer gel dosimeters were assessed using optical spectrophotometry and MRI more than 48 hours (8 half-lives) after preparation. The dose delivered to the each P6 vial was calculated empirically and also computed using GATE Monte Carlo software. Results: Spectrophotometry optical density or MRI R2 relation rate versus total activity curves were obtained and used to evaluate the relationship between the amount of gel polymerization and the dose deposited by the radionuclide. A linear dose response was exhibited up to 1000 MBq (corresponding to 20Gy) and was still behaving monotonically at 5000 MBq. Conclusion: PAGAT polymer gel dosimeters offer the potential to measure radiation dose from Tc-99m three-dimensionally. Further work will extend these techniques to use with I-131, F-18, Y-90 and other particle emitting radionuclides.

AB - Purpose: The use of polymer gels dosimeters were investigated as suitable dosimeters for assessing internal radionuclide dosimetry of Tc-99m. Material and Methods: 25-5000 MBq of Tc-99m was introduced by syringe into aqueous PAGAT polymer gel dosimeter mixtures which had been sealed in nitrogen-filled P6 glass vials. After irradiation the polymer gel dosimeters were assessed using optical spectrophotometry and MRI more than 48 hours (8 half-lives) after preparation. The dose delivered to the each P6 vial was calculated empirically and also computed using GATE Monte Carlo software. Results: Spectrophotometry optical density or MRI R2 relation rate versus total activity curves were obtained and used to evaluate the relationship between the amount of gel polymerization and the dose deposited by the radionuclide. A linear dose response was exhibited up to 1000 MBq (corresponding to 20Gy) and was still behaving monotonically at 5000 MBq. Conclusion: PAGAT polymer gel dosimeters offer the potential to measure radiation dose from Tc-99m three-dimensionally. Further work will extend these techniques to use with I-131, F-18, Y-90 and other particle emitting radionuclides.

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DO - 10.1118/1.2961546

M3 - Meeting abstract

VL - 35

SP - 2676

EP - 2676

JO - Medical Physics

T2 - Medical Physics

JF - Medical Physics

SN - 0094-2405

IS - 6

ER -