Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies

Jean Bousquet; Jean-Paul Cristol; Wienczyslawa Czarlewski; Josep M. Anto; Adrian Martineau; Tari Haahtela; Susana C. Fonseca; Guido Iaccarino; Hubert Blain; Alessandro Fiocchi; G. Walter Canonica; Joao A. Fonseca; Alain Vidal; Hak-Jong Choi; Hyun Ju Kim; Vincent Le Moing; Jacques Reynes; Aziz Sheikh; Cezmi A. Akdis; Torsten Zuberbier; ARIA group

doi:10.1186/s13601-020-00362-7

Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies

Jean Bousquet, Jean-Paul Cristol, Wienczyslawa Czarlewski, Josep M. Anto, Adrian Martineau, Tari Haahtela, Susana C. Fonseca, Guido Iaccarino, Hubert Blain, Alessandro Fiocchi, G. Walter Canonica, Joao A. Fonseca, Alain Vidal, Hak-Jong Choi, Hyun Ju Kim, Vincent Le Moing, Jacques Reynes, Aziz Sheikh, Cezmi A. Akdis, Torsten ZuberbierARIA group

Research output: Contribution to journal › Review article › peer-review

66 Citations (Scopus)

13 Downloads (Pure)

Abstract

There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPARγ:Peroxisome proliferator-activated receptor, NFκB: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2α:Elongation initiation factor 2α). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT ₁R axis (AT ₁R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity.

Original language	English
Article number	58
Pages (from-to)	1-18
Number of pages	18
Journal	Clinical and Translational Allergy
Volume	10
DOIs	https://doi.org/10.1186/s13601-020-00362-7
Publication status	Published - 3 Dec 2020
Externally published	Yes

Bibliographical note

Copyright the Author(s) 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

COVID-19
Foods
Insulin resistance
Nrf2
Nutrients
Obesity
TRPA1

Access to Document

10.1186/s13601-020-00362-7Licence: CC BY

Publisher version (open access)Final published version, 1.61 MBLicence: CC BY

Cite this

Bousquet, J., Cristol, J.-P., Czarlewski, W., Anto, J. M., Martineau, A., Haahtela, T., Fonseca, S. C., Iaccarino, G., Blain, H., Fiocchi, A., Canonica, G. W., Fonseca, J. A., Vidal, A., Choi, H.-J., Kim, H. J., Le Moing, V., Reynes, J., Sheikh, A., Akdis, C. A., ... ARIA group (2020). Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies. Clinical and Translational Allergy, 10, 1-18. Article 58. https://doi.org/10.1186/s13601-020-00362-7

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title = "Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies",

abstract = "There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPARγ:Peroxisome proliferator-activated receptor, NFκB: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2α:Elongation initiation factor 2α). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT 1R axis (AT 1R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity.",

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note = "Copyright the Author(s) 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2020",

month = dec,

day = "3",

doi = "10.1186/s13601-020-00362-7",

language = "English",

volume = "10",

pages = "1--18",

journal = "Clinical and Translational Allergy",

issn = "2045-7022",

publisher = "Springer, Springer Nature",

}

Bousquet, J, Cristol, J-P, Czarlewski, W, Anto, JM, Martineau, A, Haahtela, T, Fonseca, SC, Iaccarino, G, Blain, H, Fiocchi, A, Canonica, GW, Fonseca, JA, Vidal, A, Choi, H-J, Kim, HJ, Le Moing, V, Reynes, J, Sheikh, A, Akdis, CA, Zuberbier, T & ARIA group 2020, 'Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies', Clinical and Translational Allergy, vol. 10, 58, pp. 1-18. https://doi.org/10.1186/s13601-020-00362-7

TY - JOUR

T1 - Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies

AU - Bousquet, Jean

AU - Cristol, Jean-Paul

AU - Czarlewski, Wienczyslawa

AU - Anto, Josep M.

AU - Martineau, Adrian

AU - Haahtela, Tari

AU - Fonseca, Susana C.

AU - Iaccarino, Guido

AU - Blain, Hubert

AU - Fiocchi, Alessandro

AU - Canonica, G. Walter

AU - Fonseca, Joao A.

AU - Vidal, Alain

AU - Choi, Hak-Jong

AU - Kim, Hyun Ju

AU - Le Moing, Vincent

AU - Reynes, Jacques

AU - Sheikh, Aziz

AU - Akdis, Cezmi A.

AU - Zuberbier, Torsten

AU - ARIA group

AU - Abdul Latiff, A.H.

AU - Abdullah, B.

AU - Aberer, W.

AU - Abusada, N.

AU - Adcock, I.

AU - Afani, A.

AU - Agache, I.

AU - Aggelidis, X.

AU - Agustin, J.

AU - Akdis, M.

AU - Al-Ahmad, M.

AU - Al-Zahab Bassam, A.

AU - Alburdan, H.

AU - Aldrey-Palacios, O.

AU - Alvarez Cuesta, E.

AU - Alwan Salman, H.

AU - Alzaabi, A.

AU - Amade, S.

AU - Ambrocio, G.

AU - Angles, R.

AU - Annesi-Maesano, I.

AU - Ansotegui, I.J.

AU - Ara Bardajo, P.

AU - Arasi, S.

AU - Arrais, M.

AU - Arshad, H.

AU - Artesani, M.-C.

AU - Asayag, E.

AU - Avolio, F.

AU - Azhari, K.

AU - Bachert, C.

AU - Bagnasco, D.

AU - Baiardini, I.

AU - Bajrovic, N.

AU - Bakakos, P.

AU - Bakeyala Mongono, S.

AU - Balotro-Torres, C.

AU - Barba, S.

AU - Barbara, C.

AU - Barbosa, E.

AU - Barreto, B.

AU - Bartra, J.

AU - Basagana, X.

AU - Bateman, E.D.

AU - Battur, L.

AU - Bedbrook, A.

AU - Bedolla Barajas, M.

AU - Beghé, B.

AU - Bekere, A.

AU - Bel, E.

AU - Ben Kheder, A.

AU - Benson, M.

AU - Berghea, E.-C.

AU - Bergmann, K.-C.

AU - Bernardini, R.

AU - Bernstein, D.

AU - Bewick, M.

AU - Bialek, S.

AU - Bialoszewski, A.

AU - Bieber, T.

AU - Billo, N.E.

AU - Bilo, M.-B.

AU - Bindslev-Jensen, C.

AU - Bjermer, L.

AU - Bobolea, I.

AU - Bochenska Marciniak, M.

AU - Bond, C.

AU - Boner, A.

AU - Bonini, M.

AU - Bonini, S.

AU - Bosnic-Anticevich, S.

AU - Bosse, I.

AU - Botskariova, S.

AU - Bouchard, J.

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AU - Bourret, R.

AU - Bousquet, P.

AU - Braido, F.

AU - Briggs, A.

AU - Brightling, C.E.

AU - Brozek, J.

AU - Brussino, L.

AU - Buhl, R.

AU - Bumbacea, R.

AU - Buquicchio, R.

AU - Burguete Cabañas, M.-T.

AU - Bush, A.

AU - Busse, W.W.

AU - Buters, J.

AU - Caballero-Fonseca, F.

AU - Calderon, M.A.

AU - Calvo, M.

AU - Camargos, P.

AU - Camuzat, T.

AU - Canevari, F.

AU - Cano, A.

AU - Capriles-Hulett, A.

AU - Caraballo, L.

AU - Cardona, V.

AU - Carlsen, K.-H.

AU - Carmona Pirez, J.

AU - Caro, J.

AU - Carr, W.

AU - Carreiro-Martins, P.

AU - Carreon-Asuncion, F.

AU - Carriazo, A.-M.

AU - Carrion y Ribas, C.

AU - Casale, T.

AU - Castor, M.-A.

AU - Castro, E.

AU - Caviglia, A.G.

AU - Cecchi, L.

AU - Cepeda Sarabia, A.

AU - Chalubinski, M.

AU - Chandrasekharan, R.

AU - Chang, Y.-S.

AU - Chato-Andeza, V.

AU - Chatzi, L.

AU - Chatzidaki, C.

AU - Chavannes, N.H.

AU - Chaves Loureiro, C.

AU - Chavez Garcia, A.-A.

AU - Chelninska, M.

AU - Chen, Y.

AU - Cheng, L.

AU - Chinthrajah, S.

AU - Chivato, T.

AU - Chkhartishvili, E.

AU - Christoff, G.

AU - Chrystyn, H.

AU - Chu, D.K.

AU - Chua, A.

AU - Chuchalin, A.

AU - Chung, K.F.

AU - Cicerán, A.

AU - Cingi, C.

AU - Ciprandi, G.

AU - Cirule, I.

AU - Coelho, A.-C.

AU - Compalati, E.

AU - Constantinidis, J.

AU - Correia de Sousa, J.

AU - Costa, E.M.

AU - Costa, D.

AU - del Carmen Costa Domínguez, M.

AU - Coste, A.

AU - Cottini, M.

AU - Cox, L.

AU - Crisci, C.

AU - Crivellaro, M.A.

AU - Cruz, A.A.

AU - Cullen, J.

AU - Custovic, A.

AU - Cvetkovski, B.

AU - D’Amato, G.

AU - da Silva, J.

AU - Dahl, R.

AU - Dahlen, S.-E.

AU - Daniilidis, V.

AU - Darjazini Nahhas, L.

AU - Darsow, U.

AU - Davies, J.

AU - de Blay, F.

AU - De Feo, G.

AU - De Guia, E.

AU - De la Torre Navarrete, J.-R.

AU - De los Santos, C.

AU - De Manuel Keenoy, E.

AU - De Vries, G.

AU - Deleanu, D.

AU - Demoly, P.

AU - Denburg, J.

AU - Devillier, P.

AU - Didier, A.

AU - Dimic Janjic, S.

AU - Dimou, M.

AU - Dinh-Xuan, A.T.

AU - Djukanovic, R.

AU - Do Ceu Texeira, M.

AU - Dokic, D.

AU - Domínguez Silva, M.G.

AU - Douagui, H.

AU - Douladiris, N.

AU - Doulaptsi, M.

AU - Dray, G.

AU - Dubakiene, R.

AU - Dupas, E.

AU - Durham, S.

AU - Duse, M.

AU - Dykewicz, M.

AU - Ebo, D.

AU - Edelbaher, N.

AU - Eiwegger, T.

AU - Eklund, P.

AU - El-Gamal, Y.

AU - El-Sayed, Z.A.

AU - El-Sayed, S.S.

AU - El-Seify, M.

AU - Emuzyte, R.

AU - Enecilla, L.

AU - Erhola, M.

AU - Espinoza, H.

AU - Espinoza Contreras, J.G.

AU - Farrell, J.

AU - Fernandez, L.

AU - Fimbres Jimenez, P.

AU - Fink Wagner, A.

AU - Fokkens, W.J.

AU - Folletti, L.

AU - Fontaine, J.-F.

AU - Forastiere, F.

AU - Fuentes Pèrez, J.M.

AU - Gaerlan-Resureccion, E.

AU - Gaga, M.

AU - Gálvez Romero, J.L.

AU - Gamkrelidze, A.

AU - Garcia, A.

AU - García Cobas, C.Y.

AU - de la Luz Hortensia García Cruz, M.

AU - Ortiz, V.G.

AU - Gayraud, J.

AU - Gelardi, M.

AU - Gemicioglu, B.

AU - Gennimata, D.

AU - Young, I.

N1 - Copyright the Author(s) 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2020/12/3

Y1 - 2020/12/3

N2 - There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPARγ:Peroxisome proliferator-activated receptor, NFκB: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2α:Elongation initiation factor 2α). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT 1R axis (AT 1R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity.

AB - There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPARγ:Peroxisome proliferator-activated receptor, NFκB: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2α:Elongation initiation factor 2α). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT 1R axis (AT 1R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity.

KW - COVID-19

KW - Foods

KW - Insulin resistance

KW - Nrf2

KW - Nutrients

KW - Obesity

KW - TRPA1

UR - https://www.scopus.com/pages/publications/85098217862

U2 - 10.1186/s13601-020-00362-7

DO - 10.1186/s13601-020-00362-7

M3 - Review article

C2 - 33292691

SN - 2045-7022

VL - 10

SP - 1

EP - 18

JO - Clinical and Translational Allergy

JF - Clinical and Translational Allergy

M1 - 58

ER -

Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies

Abstract

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Keywords

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