Nucleotide sequences from yeast serine-acceptor ribonucleic acids

P. L. Bergquist*, Joan M. Robertson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


1. 1. Soluble RNA from brewer's yeast has been fractionated by partition chromatography. Five peaks of activity have been found for the acceptance of serine. 2. 2. The five seryl RNA's have been degraded by pancreatic ribonuclease (EC and the products separated by a two-dimensional mapping procedure. Virtually all the hydrolysis products mapped for each seryl RNA have been recovered in identified nucleotide sequences. 3. 3. Certain sequences, for example guanylyl-(3′ → 5′)-thymine ribonucleotide or 2-dimethylamino guanylyl (-3′ → 5′m)-cytidine 3′-phosphate, occur only in one of the five seryl acceptor RNA's. 4. 4. The significance of these findings is discussed in relation to the presently accepted nature of the genetic code and a possible role is suggested for the seryl RNA's present in smaller amounts.

Original languageEnglish
Pages (from-to)579-587
Number of pages9
JournalBBA Section Nucleic Acids And Protein Synthesis
Issue number4
Publication statusPublished - 10 Aug 1965
Externally publishedYes


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