TY - JOUR
T1 - Obesity and postoperative atrial fibrillation in patients undergoing cardiac surgery
T2 - Systematic review and meta-analysis
AU - Phan, Kevin
AU - Khuong, Jacqueline Nguyen
AU - Xu, Joshua
AU - Kanagaratnam, Aran
AU - Yan, Tristan D.
PY - 2016/8/15
Y1 - 2016/8/15
N2 - Introduction Post-operative atrial fibrillation (POAF) is one of the most common complications following cardiac surgery. However, it is unclear whether there is a relationship between obesity and POAF. We thus assessed all available evidence investigating the association between obesity and POAF, also considering any link between POAF and other post-operative conditions such as mortality, stroke, myocardial infarctions and respiratory complications. Methods Five electronic databases were searched and relevant studies were identified. Data was extracted and meta-analyzed from the identified studies. Results We found that obese patients had significantly higher odds of POAF when compared with non-obese patients (P = 0.006). There was also significant heterogeneity among the identified studies. POAF when compared with no-POAF was associated with an increased risk of stroke (P < 0.0001), 30-day mortality (P = 0.005) and respiratory complications (P < 0.00001). However, we found no significant link between POAF and myocardial infarctions (P = 0.79). Conclusions Our findings suggest that obesity is associated with a moderately higher risk of POAF. While POAF is also associated with an increased incidence of stroke, 30-day mortality and respiratory complications, further studies must be conducted before conclusions can be made about the long-term outcomes.
AB - Introduction Post-operative atrial fibrillation (POAF) is one of the most common complications following cardiac surgery. However, it is unclear whether there is a relationship between obesity and POAF. We thus assessed all available evidence investigating the association between obesity and POAF, also considering any link between POAF and other post-operative conditions such as mortality, stroke, myocardial infarctions and respiratory complications. Methods Five electronic databases were searched and relevant studies were identified. Data was extracted and meta-analyzed from the identified studies. Results We found that obese patients had significantly higher odds of POAF when compared with non-obese patients (P = 0.006). There was also significant heterogeneity among the identified studies. POAF when compared with no-POAF was associated with an increased risk of stroke (P < 0.0001), 30-day mortality (P = 0.005) and respiratory complications (P < 0.00001). However, we found no significant link between POAF and myocardial infarctions (P = 0.79). Conclusions Our findings suggest that obesity is associated with a moderately higher risk of POAF. While POAF is also associated with an increased incidence of stroke, 30-day mortality and respiratory complications, further studies must be conducted before conclusions can be made about the long-term outcomes.
UR - http://www.scopus.com/inward/record.url?scp=84966312284&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2016.05.002
DO - 10.1016/j.ijcard.2016.05.002
M3 - Review article
C2 - 27179208
AN - SCOPUS:84966312284
VL - 217
SP - 49
EP - 57
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
ER -