Obesity and the microvasculature: a systematic review and meta-analysis

Adrien Boillot; Sophia Zoungas; Paul Mitchell; Ronald Klein; Barbara Klein; Mohammad Kamran Ikram; Caroline Klaver; Jie Jin Wang; Bamini Gopinath; E. Shyong Tai; Aljoscha Steffen Neubauer; Serge Hercberg; Laima Brazionis; Seang-Mei Saw; Tien-Yin Wong; Sebastien Czernichow; META-EYE Study Group

doi:10.1371/journal.pone.0052708

Obesity and the microvasculature: a systematic review and meta-analysis

Adrien Boillot, Sophia Zoungas, Paul Mitchell, Ronald Klein, Barbara Klein, Mohammad Kamran Ikram, Caroline Klaver, Jie Jin Wang, Bamini Gopinath, E. Shyong Tai, Aljoscha Steffen Neubauer, Serge Hercberg, Laima Brazionis, Seang-Mei Saw, Tien-Yin Wong, Sebastien Czernichow^*, META-EYE Study Group

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Background
Overweight and obesity are thought to significantly influence a person's risk of cardiovascular disease, possibly via its effect on the microvasculature. Retinal vascular caliber is a surrogate marker of microvascular disease and a predictor of cardiovascular events. The aim of this systematic review and meta-analysis was to determine the association between body mass index (BMI) and retinal vascular caliber.

Methods and Findings
Relevant studies were identified by searches of the MEDLINE and EMBASE databases from 1966 to August 2011. Standardized forms were used for data extraction. Among over 44,000 individuals, obese subjects had narrower arteriolar and wider venular calibers when compared with normal weight subjects, independent of conventional cardiovascular risk factors. In adults, a 1 kg/m2 increase in BMI was associated with a difference of 0.07 μm [95% CI: −0.08; −0.06] in arteriolar caliber and 0.22 μm [95% CI: 0.21; 0.23] in venular caliber. Similar results were found for children.

Conclusions
Higher BMI is associated with narrower retinal arteriolar and wider venular calibers. Further prospective studies are needed to examine whether a causative relationship between BMI and retinal microcirculation exists.

Original language	English
Article number	e52708
Pages (from-to)	1-9
Number of pages	9
Journal	PLoS ONE
Volume	8
Issue number	2
DOIs	https://doi.org/10.1371/journal.pone.0052708
Publication status	Published - Feb 2013
Externally published	Yes

Bibliographical note

Copyright the Author(s) 2013. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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Publisher version (open access)Final published version, 643 KBLicence: CC BY

Cite this

Boillot, A., Zoungas, S., Mitchell, P., Klein, R., Klein, B., Ikram, M. K., Klaver, C., Wang, J. J., Gopinath, B., Tai, E. S., Neubauer, A. S., Hercberg, S., Brazionis, L., Saw, S.-M., Wong, T.-Y., Czernichow, S., & META-EYE Study Group (2013). Obesity and the microvasculature: a systematic review and meta-analysis. PLoS ONE, 8(2), 1-9. Article e52708. https://doi.org/10.1371/journal.pone.0052708

@article{bdd01378999a46c6846c4073b6c0d7ce,

title = "Obesity and the microvasculature: a systematic review and meta-analysis",

abstract = "BackgroundOverweight and obesity are thought to significantly influence a person's risk of cardiovascular disease, possibly via its effect on the microvasculature. Retinal vascular caliber is a surrogate marker of microvascular disease and a predictor of cardiovascular events. The aim of this systematic review and meta-analysis was to determine the association between body mass index (BMI) and retinal vascular caliber.Methods and FindingsRelevant studies were identified by searches of the MEDLINE and EMBASE databases from 1966 to August 2011. Standardized forms were used for data extraction. Among over 44,000 individuals, obese subjects had narrower arteriolar and wider venular calibers when compared with normal weight subjects, independent of conventional cardiovascular risk factors. In adults, a 1 kg/m2 increase in BMI was associated with a difference of 0.07 μm [95% CI: −0.08; −0.06] in arteriolar caliber and 0.22 μm [95% CI: 0.21; 0.23] in venular caliber. Similar results were found for children.ConclusionsHigher BMI is associated with narrower retinal arteriolar and wider venular calibers. Further prospective studies are needed to examine whether a causative relationship between BMI and retinal microcirculation exists.",

author = "Adrien Boillot and Sophia Zoungas and Paul Mitchell and Ronald Klein and Barbara Klein and Ikram, {Mohammad Kamran} and Caroline Klaver and Wang, {Jie Jin} and Bamini Gopinath and Tai, {E. Shyong} and Neubauer, {Aljoscha Steffen} and Serge Hercberg and Laima Brazionis and Seang-Mei Saw and Tien-Yin Wong and Sebastien Czernichow and {META-EYE Study Group}",

note = "Copyright the Author(s) 2013. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2013",

month = feb,

doi = "10.1371/journal.pone.0052708",

language = "English",

volume = "8",

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Boillot, A, Zoungas, S, Mitchell, P, Klein, R, Klein, B, Ikram, MK, Klaver, C, Wang, JJ, Gopinath, B, Tai, ES, Neubauer, AS, Hercberg, S, Brazionis, L, Saw, S-M, Wong, T-Y, Czernichow, S & META-EYE Study Group 2013, 'Obesity and the microvasculature: a systematic review and meta-analysis', PLoS ONE, vol. 8, no. 2, e52708, pp. 1-9. https://doi.org/10.1371/journal.pone.0052708

TY - JOUR

T1 - Obesity and the microvasculature

T2 - a systematic review and meta-analysis

AU - Boillot, Adrien

AU - Zoungas, Sophia

AU - Mitchell, Paul

AU - Klein, Ronald

AU - Klein, Barbara

AU - Ikram, Mohammad Kamran

AU - Klaver, Caroline

AU - Wang, Jie Jin

AU - Gopinath, Bamini

AU - Tai, E. Shyong

AU - Neubauer, Aljoscha Steffen

AU - Hercberg, Serge

AU - Brazionis, Laima

AU - Saw, Seang-Mei

AU - Wong, Tien-Yin

AU - Czernichow, Sebastien

AU - META-EYE Study Group

N1 - Copyright the Author(s) 2013. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2013/2

Y1 - 2013/2

N2 - BackgroundOverweight and obesity are thought to significantly influence a person's risk of cardiovascular disease, possibly via its effect on the microvasculature. Retinal vascular caliber is a surrogate marker of microvascular disease and a predictor of cardiovascular events. The aim of this systematic review and meta-analysis was to determine the association between body mass index (BMI) and retinal vascular caliber.Methods and FindingsRelevant studies were identified by searches of the MEDLINE and EMBASE databases from 1966 to August 2011. Standardized forms were used for data extraction. Among over 44,000 individuals, obese subjects had narrower arteriolar and wider venular calibers when compared with normal weight subjects, independent of conventional cardiovascular risk factors. In adults, a 1 kg/m2 increase in BMI was associated with a difference of 0.07 μm [95% CI: −0.08; −0.06] in arteriolar caliber and 0.22 μm [95% CI: 0.21; 0.23] in venular caliber. Similar results were found for children.ConclusionsHigher BMI is associated with narrower retinal arteriolar and wider venular calibers. Further prospective studies are needed to examine whether a causative relationship between BMI and retinal microcirculation exists.

AB - BackgroundOverweight and obesity are thought to significantly influence a person's risk of cardiovascular disease, possibly via its effect on the microvasculature. Retinal vascular caliber is a surrogate marker of microvascular disease and a predictor of cardiovascular events. The aim of this systematic review and meta-analysis was to determine the association between body mass index (BMI) and retinal vascular caliber.Methods and FindingsRelevant studies were identified by searches of the MEDLINE and EMBASE databases from 1966 to August 2011. Standardized forms were used for data extraction. Among over 44,000 individuals, obese subjects had narrower arteriolar and wider venular calibers when compared with normal weight subjects, independent of conventional cardiovascular risk factors. In adults, a 1 kg/m2 increase in BMI was associated with a difference of 0.07 μm [95% CI: −0.08; −0.06] in arteriolar caliber and 0.22 μm [95% CI: 0.21; 0.23] in venular caliber. Similar results were found for children.ConclusionsHigher BMI is associated with narrower retinal arteriolar and wider venular calibers. Further prospective studies are needed to examine whether a causative relationship between BMI and retinal microcirculation exists.

U2 - 10.1371/journal.pone.0052708

DO - 10.1371/journal.pone.0052708

M3 - Article

C2 - 23405065

SN - 1932-6203

VL - 8

SP - 1

EP - 9

JO - PLoS ONE

JF - PLoS ONE

IS - 2

M1 - e52708

ER -

Obesity and the microvasculature: a systematic review and meta-analysis

Abstract

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